Structure-activity relationship of conformationally constrained peptidomimetics for antiproliferative activity in HER2-overexpressing breast cancer cell lines

Human epidermal growth factor receptor 2 (HER2) is a member of the human epidermal growth factor receptor kinases and is involved in a signaling cascade for cell growth and differentiation. It is well established that HER2-mediated heterodimerization has important implications in cancer. Deregulatio...

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Veröffentlicht in:MedChemComm 2011-01, Vol.2 (8), p.752-759
Hauptverfasser: Banappagari, Sashikanth, Ronald, Sharon, Satyanarayanajois, Seetharama D
Format: Artikel
Sprache:eng
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