An essential role in liver development for transcription factor XBP-1

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hema...

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Veröffentlicht in:	Genes & development 2000-01, Vol.14 (2), p.152-157
Hauptverfasser:	Reimold, A M, Etkin, A, Clauss, I, Perkins, A, Friend, D S, Zhang, J, Horton, H F, Scott, A, Orkin, S H, Byrne, M C, Grusby, M J, Glimcher, L H
Format:	Artikel
Sprache:	eng
Schlagworte:	aFP gene Animals Apoptosis - genetics CREB/ATF protein DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Embryonic and Fetal Development - genetics Gene Targeting Genes, Lethal - genetics Hepatectomy Liver - abnormalities Liver - embryology Liver - metabolism Mice Mice, Knockout Regulatory Factor X Transcription Factors Research Communication Stem Cells Transcription Factors - biosynthesis Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - physiology X-Box Binding Protein 1 XBP-1 protein
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