Rho GTPase regulation of α-synuclein and VMAT2: Implications for pathogenesis of Parkinson's disease

Accumulation of α-synuclein (Asyn) in neuronal perikarya and dystrophic neurites is characteristic of idiopathic and familial Parkinson's disease. In this study, we investigated the relationship between α-synuclein expression and neurite outgrowth-maturation using MN9D dopaminergic cells and de...

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Veröffentlicht in:	Molecular and cellular neuroscience 2011-09, Vol.48 (1), p.29-37
Hauptverfasser:	Zhou, Zhigang, Kim, Jeeyong, Insolera, Ryan, Peng, Xiangmin, Fink, David J., Mata, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - genetics alpha-Synuclein - metabolism Animals C3 transferase Cell Line Cyclic AMP - metabolism Enzyme Activation GATA2 Transcription Factor - genetics GATA2 Transcription Factor - metabolism Mice Neurites - physiology Neurites - ultrastructure Neurons - cytology Neurons - physiology Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson's disease Protein Kinase C-alpha - metabolism rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism Rho GTPase Serum Response Factor - genetics Serum Response Factor - metabolism Synuclein Trans-Activators - genetics Trans-Activators - metabolism Vesicular Monoamine Transport Proteins - genetics Vesicular Monoamine Transport Proteins - metabolism
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