Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers
To examine the associations between postmortem Alzheimer disease (AD) neuropathology and autopsy-verified cardiovascular disease. The authors examined 99 subjects (mean age at death = 87.6; SD = 8.7) from the Mount Sinai School of Medicine Department of Psychiatry Brain Bank who were devoid of cereb...
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| Veröffentlicht in: | Neurology 2006-05, Vol.66 (9), p.1399-1404 |
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| creator | BEERI, M. S RAPP, M ROSENDORFF, C HAROUTUNIAN, V SILVERMAN, J. M SCHMEIDLER, J GROSSMAN, H. T FALLON, J. T PUROHIT, D. P PERI, D. P SIDDIQUI, A LESSER, G |
| description | To examine the associations between postmortem Alzheimer disease (AD) neuropathology and autopsy-verified cardiovascular disease.
The authors examined 99 subjects (mean age at death = 87.6; SD = 8.7) from the Mount Sinai School of Medicine Department of Psychiatry Brain Bank who were devoid of cerebrovascular disease-associated lesions or of non-AD-related neuropathology. Density of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) as well as coronary artery and aortic atherosclerosis, left ventricular wall thickness, and heart weight were measured. Partial correlations were used to assess the associations of the four cardiovascular variables with NPs and NFTs in the hippocampus, entorhinal cortex, and multiple regions of the cerebral cortex after controlling for age at death, sex, dementia severity, body mass index, and ApoE genotype. These analyses were also repeated separately for ApoE4 carriers and noncarriers.
The extent of coronary artery disease and to a lesser extent atherosclerosis were significantly associated with the density of cardinal neuropathologic lesions of AD in this autopsy sample (significant correlations between 0.22 and 0.29). These associations were more pronounced for the ApoE4 allele carriers (n = 42; significant correlations between 0.34 and 0.47).
The degree of coronary artery disease is independently associated with the cardinal neuropathological lesions of Alzheimer disease. These associations are primarily attributable to individuals with the ApoE4 allele. |
| doi_str_mv | 10.1212/01.wnl.0000210447.19748.0b |
| format | Article |
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The authors examined 99 subjects (mean age at death = 87.6; SD = 8.7) from the Mount Sinai School of Medicine Department of Psychiatry Brain Bank who were devoid of cerebrovascular disease-associated lesions or of non-AD-related neuropathology. Density of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) as well as coronary artery and aortic atherosclerosis, left ventricular wall thickness, and heart weight were measured. Partial correlations were used to assess the associations of the four cardiovascular variables with NPs and NFTs in the hippocampus, entorhinal cortex, and multiple regions of the cerebral cortex after controlling for age at death, sex, dementia severity, body mass index, and ApoE genotype. These analyses were also repeated separately for ApoE4 carriers and noncarriers.
The extent of coronary artery disease and to a lesser extent atherosclerosis were significantly associated with the density of cardinal neuropathologic lesions of AD in this autopsy sample (significant correlations between 0.22 and 0.29). These associations were more pronounced for the ApoE4 allele carriers (n = 42; significant correlations between 0.34 and 0.47).
The degree of coronary artery disease is independently associated with the cardinal neuropathological lesions of Alzheimer disease. These associations are primarily attributable to individuals with the ApoE4 allele.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/01.wnl.0000210447.19748.0b</identifier><identifier>PMID: 16682673</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged, 80 and over ; Alleles ; Alzheimer Disease - complications ; Alzheimer Disease - genetics ; Alzheimer Disease - pathology ; Aortic Diseases - complications ; Aortic Diseases - genetics ; Apolipoprotein E4 ; Apolipoproteins E - genetics ; Atherosclerosis - complications ; Atherosclerosis - genetics ; Biological and medical sciences ; Brain - pathology ; Cardiomegaly - complications ; Cardiomegaly - genetics ; Cardiomegaly - pathology ; Comorbidity ; Coronary Disease - complications ; Coronary Disease - genetics ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Genetic Predisposition to Disease ; Genotype ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Heart Ventricles - pathology ; Humans ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurofibrillary Tangles ; Neurology ; Organ Size ; Plaque, Amyloid ; Severity of Illness Index</subject><ispartof>Neurology, 2006-05, Vol.66 (9), p.1399-1404</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright © 2006 by AAN Enterprises, Inc. 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-a647aa0d095d5358ec261b9fa2f4b27559ad1ce22ffa84f1dc8470d160fc38623</citedby><cites>FETCH-LOGICAL-c454t-a647aa0d095d5358ec261b9fa2f4b27559ad1ce22ffa84f1dc8470d160fc38623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17758945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16682673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BEERI, M. S</creatorcontrib><creatorcontrib>RAPP, M</creatorcontrib><creatorcontrib>ROSENDORFF, C</creatorcontrib><creatorcontrib>HAROUTUNIAN, V</creatorcontrib><creatorcontrib>SILVERMAN, J. M</creatorcontrib><creatorcontrib>SCHMEIDLER, J</creatorcontrib><creatorcontrib>GROSSMAN, H. T</creatorcontrib><creatorcontrib>FALLON, J. T</creatorcontrib><creatorcontrib>PUROHIT, D. P</creatorcontrib><creatorcontrib>PERI, D. P</creatorcontrib><creatorcontrib>SIDDIQUI, A</creatorcontrib><creatorcontrib>LESSER, G</creatorcontrib><title>Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers</title><title>Neurology</title><addtitle>Neurology</addtitle><description>To examine the associations between postmortem Alzheimer disease (AD) neuropathology and autopsy-verified cardiovascular disease.
The authors examined 99 subjects (mean age at death = 87.6; SD = 8.7) from the Mount Sinai School of Medicine Department of Psychiatry Brain Bank who were devoid of cerebrovascular disease-associated lesions or of non-AD-related neuropathology. Density of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) as well as coronary artery and aortic atherosclerosis, left ventricular wall thickness, and heart weight were measured. Partial correlations were used to assess the associations of the four cardiovascular variables with NPs and NFTs in the hippocampus, entorhinal cortex, and multiple regions of the cerebral cortex after controlling for age at death, sex, dementia severity, body mass index, and ApoE genotype. These analyses were also repeated separately for ApoE4 carriers and noncarriers.
The extent of coronary artery disease and to a lesser extent atherosclerosis were significantly associated with the density of cardinal neuropathologic lesions of AD in this autopsy sample (significant correlations between 0.22 and 0.29). These associations were more pronounced for the ApoE4 allele carriers (n = 42; significant correlations between 0.34 and 0.47).
The degree of coronary artery disease is independently associated with the cardinal neuropathological lesions of Alzheimer disease. These associations are primarily attributable to individuals with the ApoE4 allele.</description><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - pathology</subject><subject>Aortic Diseases - complications</subject><subject>Aortic Diseases - genetics</subject><subject>Apolipoprotein E4</subject><subject>Apolipoproteins E - genetics</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - genetics</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Cardiomegaly - complications</subject><subject>Cardiomegaly - genetics</subject><subject>Cardiomegaly - pathology</subject><subject>Comorbidity</subject><subject>Coronary Disease - complications</subject><subject>Coronary Disease - genetics</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Heart Ventricles - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurofibrillary Tangles</subject><subject>Neurology</subject><subject>Organ Size</subject><subject>Plaque, Amyloid</subject><subject>Severity of Illness Index</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkV1LHDEUhkOx1NX2L8hQ0LuZ5juZXgjL4hcI9qKF3pRwJpO4kdnJmswq9tcbdXHb3JyL9zlvEh6EvhLcEEroN0yax3FocDmUYM5VQ1rFdYO7D2hGBJW1ZPT3HpqVXNdMK72PDnK-w7iEqv2E9omUmkrFZujPIqY4QnqqIE2ujD5kB9lVIVeQc7QBJtdXj2FaVvPh79KFlUvv0Og2Ka5hWsYh3j5VYazmP27OeGUhpeBS_ow-ehiy-7Kdh-jX-dnPxWV9fXNxtZhf15YLPtUguQLAPW5FL5jQzlJJutYD9byjSogWemIdpd6D5p70VnOFeyKxt0xLyg7R6VvvetOtXG_dOCUYzDqFVfmaiRDM_8kYluY2PhhGJMPtS8HJtiDF-43Lk1mFbN0wwOjiJhupWoGlEgX8_gbaFHNOzr9fQrB5sWMwMcWO2dkxr3YM7sry0b_P3K1udRTgeAtAtjD4BKMNeccpJXTLBXsGgdCcPQ</recordid><startdate>20060509</startdate><enddate>20060509</enddate><creator>BEERI, M. S</creator><creator>RAPP, M</creator><creator>ROSENDORFF, C</creator><creator>HAROUTUNIAN, V</creator><creator>SILVERMAN, J. M</creator><creator>SCHMEIDLER, J</creator><creator>GROSSMAN, H. T</creator><creator>FALLON, J. T</creator><creator>PUROHIT, D. P</creator><creator>PERI, D. P</creator><creator>SIDDIQUI, A</creator><creator>LESSER, G</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060509</creationdate><title>Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers</title><author>BEERI, M. S ; RAPP, M ; ROSENDORFF, C ; HAROUTUNIAN, V ; SILVERMAN, J. M ; SCHMEIDLER, J ; GROSSMAN, H. T ; FALLON, J. T ; PUROHIT, D. P ; PERI, D. 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Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Heart Ventricles - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurofibrillary Tangles</topic><topic>Neurology</topic><topic>Organ Size</topic><topic>Plaque, Amyloid</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BEERI, M. S</creatorcontrib><creatorcontrib>RAPP, M</creatorcontrib><creatorcontrib>ROSENDORFF, C</creatorcontrib><creatorcontrib>HAROUTUNIAN, V</creatorcontrib><creatorcontrib>SILVERMAN, J. M</creatorcontrib><creatorcontrib>SCHMEIDLER, J</creatorcontrib><creatorcontrib>GROSSMAN, H. T</creatorcontrib><creatorcontrib>FALLON, J. T</creatorcontrib><creatorcontrib>PUROHIT, D. P</creatorcontrib><creatorcontrib>PERI, D. P</creatorcontrib><creatorcontrib>SIDDIQUI, A</creatorcontrib><creatorcontrib>LESSER, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BEERI, M. S</au><au>RAPP, M</au><au>ROSENDORFF, C</au><au>HAROUTUNIAN, V</au><au>SILVERMAN, J. M</au><au>SCHMEIDLER, J</au><au>GROSSMAN, H. T</au><au>FALLON, J. T</au><au>PUROHIT, D. P</au><au>PERI, D. P</au><au>SIDDIQUI, A</au><au>LESSER, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2006-05-09</date><risdate>2006</risdate><volume>66</volume><issue>9</issue><spage>1399</spage><epage>1404</epage><pages>1399-1404</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>To examine the associations between postmortem Alzheimer disease (AD) neuropathology and autopsy-verified cardiovascular disease.
The authors examined 99 subjects (mean age at death = 87.6; SD = 8.7) from the Mount Sinai School of Medicine Department of Psychiatry Brain Bank who were devoid of cerebrovascular disease-associated lesions or of non-AD-related neuropathology. Density of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) as well as coronary artery and aortic atherosclerosis, left ventricular wall thickness, and heart weight were measured. Partial correlations were used to assess the associations of the four cardiovascular variables with NPs and NFTs in the hippocampus, entorhinal cortex, and multiple regions of the cerebral cortex after controlling for age at death, sex, dementia severity, body mass index, and ApoE genotype. These analyses were also repeated separately for ApoE4 carriers and noncarriers.
The extent of coronary artery disease and to a lesser extent atherosclerosis were significantly associated with the density of cardinal neuropathologic lesions of AD in this autopsy sample (significant correlations between 0.22 and 0.29). These associations were more pronounced for the ApoE4 allele carriers (n = 42; significant correlations between 0.34 and 0.47).
The degree of coronary artery disease is independently associated with the cardinal neuropathological lesions of Alzheimer disease. These associations are primarily attributable to individuals with the ApoE4 allele.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16682673</pmid><doi>10.1212/01.wnl.0000210447.19748.0b</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurology, 2006-05, Vol.66 (9), p.1399-1404 |
| issn | 0028-3878 1526-632X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Aged, 80 and over Alleles Alzheimer Disease - complications Alzheimer Disease - genetics Alzheimer Disease - pathology Aortic Diseases - complications Aortic Diseases - genetics Apolipoprotein E4 Apolipoproteins E - genetics Atherosclerosis - complications Atherosclerosis - genetics Biological and medical sciences Brain - pathology Cardiomegaly - complications Cardiomegaly - genetics Cardiomegaly - pathology Comorbidity Coronary Disease - complications Coronary Disease - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Genetic Predisposition to Disease Genotype Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Heart Ventricles - pathology Humans Male Medical sciences Nervous system (semeiology, syndromes) Neurofibrillary Tangles Neurology Organ Size Plaque, Amyloid Severity of Illness Index |
| title | Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers |
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