GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expression

GABP is an ets transcription factor that regulates genes that are required for myeloid differentiation. The tetrameric GABP complex includes GABPα, which binds DNA via its ets domain, and GABPβ, which contains the transcription activation domain. To examine the role of GABP in myeloid differentiatio...

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Veröffentlicht in:	Blood 2011-08, Vol.118 (8), p.2243-2253
Hauptverfasser:	Yang, Zhong-Fa, Drumea, Karen, Cormier, James, Wang, Junling, Zhu, Xuejun, Rosmarin, Alan G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Marrow Cells - cytology Bone Marrow Cells - immunology CD11b Antigen - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology GA-Binding Protein Transcription Factor - deficiency GA-Binding Protein Transcription Factor - genetics GA-Binding Protein Transcription Factor - physiology Gene Knockout Techniques Hematologic and hematopoietic diseases Medical sciences Mice Mice, Knockout Myelopoiesis - genetics Myelopoiesis - immunology Myelopoiesis - physiology Phagocytes, Granulocytes, and Myelopoiesis Phenotype Precursor Cells, B-Lymphoid - cytology Precursor Cells, B-Lymphoid - immunology Precursor Cells, T-Lymphoid - cytology Precursor Cells, T-Lymphoid - immunology Transcription Factors - genetics Transcription Factors - physiology
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