APOE and Alzheimer disease: a major gene with semi-dominant inheritance

Apolipoprotein E ( APOE ) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient to assess these risks. We calculated AD LTR in 7351 cases and 10 132 controls from Caucasian ancestry using Rochester (USA) incidence data. A...

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Veröffentlicht in:	Molecular psychiatry 2011-09, Vol.16 (9), p.903-907
Hauptverfasser:	Genin, E, Hannequin, D, Wallon, D, Sleegers, K, Hiltunen, M, Combarros, O, Bullido, M J, Engelborghs, S, De Deyn, P, Berr, C, Pasquier, F, Dubois, B, Tognoni, G, Fiévet, N, Brouwers, N, Bettens, K, Arosio, B, Coto, E, Del Zompo, M, Mateo, I, Epelbaum, J, Frank-Garcia, A, Helisalmi, S, Porcellini, E, Pilotto, A, Forti, P, Ferri, R, Scarpini, E, Siciliano, G, Solfrizzi, V, Sorbi, S, Spalletta, G, Valdivieso, F, Vepsäläinen, S, Alvarez, V, Bosco, P, Mancuso, M, Panza, F, Nacmias, B, Bossù, P, Hanon, O, Piccardi, P, Annoni, G, Seripa, D, Galimberti, D, Licastro, F, Soininen, H, Dartigues, J-F, Kamboh, M I, Van Broeckhoven, C, Lambert, J C, Amouyel, P, Campion, D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205/2138 692/499 692/699/375/365/1283 Adult and adolescent clinical studies Age Age Factors Aged Alleles Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E Apolipoprotein E3 - genetics Apolipoprotein E4 - genetics Apolipoproteins Behavioral Sciences Biological and medical sciences Biological Psychology BRCA1 protein Breast cancer Case-Control Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Epidemiology Female Females France - epidemiology Genes Genetic aspects Genetic Predisposition to Disease - genetics Genotype Genotype & phenotype Genotypes Heredity Heredity - genetics Hospitals Humans immediate-communication Incidence Internal medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Neurodegenerative diseases Neurology Neurosciences Odds Ratio Organic mental disorders. Neuropsychology Pharmacotherapy Physiological aspects Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk factors United States - epidemiology White people
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