The Thomsen-Friedenreich Antigen-Binding Lectin Jacalin Interacts with Desmoglein-1 and Abrogates the Pathogenicity of Pemphigus Foliaceus Autoantibodies In Vivo

Pemphigus foliaceus (PF) is an autoimmune skin blistering disease mediated by pathogenic autoantibodies against the desmosomal core glycoprotein desmoglein-1 (Dsg1). This study demonstrated that the O-glycan-specific plant lectin jacalin binds Dsg1 and inhibits the interaction of Dsg1/PF IgG. N-glyc...

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Veröffentlicht in:	Journal of investigative dermatology 2010-12, Vol.130 (12), p.2773-2780
Hauptverfasser:	Li, Ning, Park, Moonhee, Zhao, Minglang, Hilario-Vargas, Julio, McInnes, David M., Prisayanh, Phillip S., Liu, Zhi, Diaz, Luis A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - metabolism Adjuvants, Immunologic - pharmacology Animals Antigen-Antibody Reactions - drug effects Antigen-Antibody Reactions - immunology Antigens, Tumor-Associated, Carbohydrate - immunology Antigens, Tumor-Associated, Carbohydrate - metabolism Arachis hypogaea Autoantibodies - drug effects Autoantibodies - immunology Autoantibodies - metabolism Biological and medical sciences Bullous diseases of the skin Dermatology Desmoglein 1 - immunology Desmoglein 1 - metabolism Epidermis - drug effects Epidermis - immunology Epidermis - pathology Glycosylation - drug effects Humans Medical sciences Mice Mice, Inbred BALB C Pemphigus - drug therapy Pemphigus - immunology Pemphigus - pathology Plant Lectins - immunology Plant Lectins - metabolism Plant Lectins - pharmacology Vicia
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