The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models

Acid sphingomyelinase (ASM) is an important early responder in inflammatory cytokine signaling. The role of ASM in retinal vascular inflammation and vessel loss associated with diabetic retinopathy is not known and represents the goal of this study. Protein and gene expression profiles were determin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2011-09, Vol.60 (9), p.2370-2378
Hauptverfasser:	OPREANU, Madalina, TIKHONENKO, Maria, KOLESNICK, Richard, GRANT, Maria B, BUSIK, Julia V, BOZACK, Svetlana, LYDIC, Todd A, REID, Gavin E, MCSORLEY, Kelly M, SOCHACKI, Andrew, PEREZ, Gloria I, ESSELMAN, Walter J, KERN, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antibodies Biological and medical sciences Capillaries - drug effects Capillaries - metabolism Capillaries - pathology Capillary Permeability - drug effects Cell culture Cells, Cultured Cholesterol Complications Cytokines Diabetes Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Diabetic retinopathy Diabetic Retinopathy - genetics Diabetic Retinopathy - metabolism Diabetic Retinopathy - pathology Docosahexaenoic Acids - pharmacology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Genetic aspects Humans Inflammation Infrared imaging systems Kinases Male Medical sciences Mice Niemann-Pick disease Proteins Rats Rats, Sprague-Dawley Research design Retinal Vessels - drug effects Retinal Vessels - metabolism Retinal Vessels - pathology Risk factors Signal transduction Sphingomyelin Phosphodiesterase - genetics Sphingomyelin Phosphodiesterase - metabolism Tumor necrosis factor-TNF Vascular endothelial growth factor Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!