Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats

Examine whether normalizing net hepatic glycogenesis restores endogenous glucose production and hepatic glucose phosphorylation in response to diabetic levels of plasma glucose and insulin in Zucker diabetic fatty rats (ZDF). Hepatic glucose and intermediate fluxes (µmol · kg(-1) · min(-1)) were mea...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2011-09, Vol.60 (9), p.2225-2233
Hauptverfasser:	TORRES, Tracy P, FUJIMOTO, Yuka, DONAHUE, E. P, PRINTZ, Richard L, HOUSEKNECHT, Karen L, TREADWAY, Judith L, SHIOTA, Masakazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Weight Carotid arteries Catheters Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucagon Gluconeogenesis - physiology Glucose Glucose - metabolism Glucose-6-Phosphatase - metabolism Glycogen - metabolism Hyperglycemia Hyperglycemia - metabolism Hyperinsulinism - metabolism Insulin Insulin - metabolism Kinases Laboratories Liver - metabolism Male Medical sciences Metabolism Musculoskeletal system Obesity - metabolism Phosphorylation Plasma Rats Rats, Zucker Research design Veins & arteries
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!