Systematic bias in high-throughput sequencing data and its correction by BEADS

Genomic sequences obtained through high-throughput sequencing are not uniformly distributed across the genome. For example, sequencing data of total genomic DNA show significant, yet unexpected enrichments on promoters and exons. This systematic bias is a particular problem for techniques such as ch...

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Veröffentlicht in:	Nucleic acids research 2011-08, Vol.39 (15), p.e103-e103
Hauptverfasser:	Cheung, Ming-Sin, Down, Thomas A, Latorre, Isabel, Ahringer, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Base Composition Caenorhabditis elegans - genetics Chromatin Immunoprecipitation DNA, Helminth - chemistry High-Throughput Nucleotide Sequencing - methods Methods Online Sequence Analysis, DNA - methods
Online-Zugang:	Volltext
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