Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding

The minichromosome maintenance (MCM) helicase complex is essential for the initiation and elongation of DNA replication in both the eukaryotic and archaeal domains. The archaeal homohexameric MCM helicase from Sulfolobus solfataricus serves as a model for understanding mechanisms of DNA unwinding. I...

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Veröffentlicht in:	Nucleic acids research 2011-08, Vol.39 (15), p.6585-6595
Hauptverfasser:	Graham, Brian W, Schauer, Grant D, Leuba, Sanford H, Trakselis, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Archaeal Proteins - chemistry Archaeal Proteins - genetics Archaeal Proteins - metabolism DNA - metabolism DNA Helicases - chemistry DNA Helicases - genetics DNA Helicases - metabolism Genome Integrity, Repair and Mutation Plant Proteins - metabolism Protein Binding Single-Strand Specific DNA and RNA Endonucleases - metabolism Sulfolobus solfataricus Sulfolobus solfataricus - enzymology
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