High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions

MALDI-MSI is a powerful technology for localizing drug and metabolite distributions in biological tissues. To enhance our understanding of tuberculosis (TB) drug efficacy and how efficiently certain drugs reach their site of action, MALDI-MSI was applied to image the distribution of the second-line...

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Veröffentlicht in:	Analytical chemistry (Washington) 2011-03, Vol.83 (6), p.2112-2118
Hauptverfasser:	Prideaux, Brendan, Dartois, Véronique, Staab, Dieter, Weiner, Danielle M, Goh, Anne, Via, Laura E, Barry, Clifton E, Stoeckli, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Anti-Bacterial Agents - pharmacokinetics Aza Compounds - pharmacokinetics Biopsy Chemistry Chromatographic methods and physical methods associated with chromatography Drugs Exact sciences and technology Female Fluoroquinolones Granuloma, Respiratory Tract - metabolism Granuloma, Respiratory Tract - pathology Ions Lung - metabolism Lung - microbiology Lung - pathology Lungs Molecular Imaging - methods Molecular Imaging - standards Moxifloxacin Other chromatographic methods Quinolines - pharmacokinetics Rabbits Reference Standards Spectrometric and optical methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - standards Tissues Tuberculosis Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - pathology
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