KIAA0101 interacts with BRCA1 and regulates centrosome number
To find genes and proteins that collaborate with BRCA1 or BRCA2 in the pathogenesis of breast cancer, we used an informatics approach and found a candidate BRCA interactor, KIAA0101, to function like BRCA1 in exerting a powerful control over centrosome number. The effect of KIAA0101 on centrosomes i...
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| Veröffentlicht in: | Molecular cancer research 2011-08, Vol.9 (8), p.1091-1099 |
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| creator | Kais, Zeina Barsky, Sanford H Mathsyaraja, Haritha Zha, Alicia Ransburgh, Derek J R He, Gang Pilarski, Robert T Shapiro, Charles L Huang, Kun Parvin, Jeffrey D |
| description | To find genes and proteins that collaborate with BRCA1 or BRCA2 in the pathogenesis of breast cancer, we used an informatics approach and found a candidate BRCA interactor, KIAA0101, to function like BRCA1 in exerting a powerful control over centrosome number. The effect of KIAA0101 on centrosomes is likely direct, as its depletion does not affect the cell cycle, KIAA0101 localizes to regions coincident with the centrosomes, and KIAA0101 binds to BRCA1. We analyzed whether KIAA0101 protein is overexpressed in breast cancer tumor samples in tissue microarrays, and we found that overexpression of KIAA0101 correlated with positive Ki67 staining, a biomarker associated with increased disease severity. Furthermore, overexpression of the KIAA0101 gene in breast tumors was found to be associated with significantly decreased survival time. This study identifies KIAA0101 as a protein important for breast tumorigenesis, and as this factor has been reported as a UV repair factor, it may link the UV damage response to centrosome control. |
| doi_str_mv | 10.1158/1541-7786.MCR-10-0503 |
| format | Article |
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The effect of KIAA0101 on centrosomes is likely direct, as its depletion does not affect the cell cycle, KIAA0101 localizes to regions coincident with the centrosomes, and KIAA0101 binds to BRCA1. We analyzed whether KIAA0101 protein is overexpressed in breast cancer tumor samples in tissue microarrays, and we found that overexpression of KIAA0101 correlated with positive Ki67 staining, a biomarker associated with increased disease severity. Furthermore, overexpression of the KIAA0101 gene in breast tumors was found to be associated with significantly decreased survival time. This study identifies KIAA0101 as a protein important for breast tumorigenesis, and as this factor has been reported as a UV repair factor, it may link the UV damage response to centrosome control.</description><identifier>ISSN: 1541-7786</identifier><identifier>EISSN: 1557-3125</identifier><identifier>DOI: 10.1158/1541-7786.MCR-10-0503</identifier><identifier>PMID: 21673012</identifier><language>eng</language><publisher>United States</publisher><subject>biomarkers ; Biomarkers, Tumor - metabolism ; BRCA1 protein ; BRCA1 Protein - genetics ; BRCA1 Protein - metabolism ; BRCA2 protein ; Breast cancer ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Cell cycle ; Centrosome - metabolism ; Centrosomes ; DNA Damage ; DNA microarrays ; Extracellular Matrix Proteins - metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Genomic Instability ; HeLa Cells ; Homologous Recombination - genetics ; Humans ; Hyaluronan Receptors - metabolism ; Informatics ; Ki-67 Antigen - analysis ; RNA, Small Interfering - genetics ; Survival ; Tumorigenesis</subject><ispartof>Molecular cancer research, 2011-08, Vol.9 (8), p.1091-1099</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-270243d6f7f9fa9b03d6040dda3db4ce99d9d3b8fd415d8aad89fe542c2cba5a3</citedby><cites>FETCH-LOGICAL-c495t-270243d6f7f9fa9b03d6040dda3db4ce99d9d3b8fd415d8aad89fe542c2cba5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3342,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21673012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kais, Zeina</creatorcontrib><creatorcontrib>Barsky, Sanford H</creatorcontrib><creatorcontrib>Mathsyaraja, Haritha</creatorcontrib><creatorcontrib>Zha, Alicia</creatorcontrib><creatorcontrib>Ransburgh, Derek J R</creatorcontrib><creatorcontrib>He, Gang</creatorcontrib><creatorcontrib>Pilarski, Robert T</creatorcontrib><creatorcontrib>Shapiro, Charles L</creatorcontrib><creatorcontrib>Huang, Kun</creatorcontrib><creatorcontrib>Parvin, Jeffrey D</creatorcontrib><title>KIAA0101 interacts with BRCA1 and regulates centrosome number</title><title>Molecular cancer research</title><addtitle>Mol Cancer Res</addtitle><description>To find genes and proteins that collaborate with BRCA1 or BRCA2 in the pathogenesis of breast cancer, we used an informatics approach and found a candidate BRCA interactor, KIAA0101, to function like BRCA1 in exerting a powerful control over centrosome number. The effect of KIAA0101 on centrosomes is likely direct, as its depletion does not affect the cell cycle, KIAA0101 localizes to regions coincident with the centrosomes, and KIAA0101 binds to BRCA1. We analyzed whether KIAA0101 protein is overexpressed in breast cancer tumor samples in tissue microarrays, and we found that overexpression of KIAA0101 correlated with positive Ki67 staining, a biomarker associated with increased disease severity. Furthermore, overexpression of the KIAA0101 gene in breast tumors was found to be associated with significantly decreased survival time. This study identifies KIAA0101 as a protein important for breast tumorigenesis, and as this factor has been reported as a UV repair factor, it may link the UV damage response to centrosome control.</description><subject>biomarkers</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>BRCA1 protein</subject><subject>BRCA1 Protein - genetics</subject><subject>BRCA1 Protein - metabolism</subject><subject>BRCA2 protein</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell cycle</subject><subject>Centrosome - metabolism</subject><subject>Centrosomes</subject><subject>DNA Damage</subject><subject>DNA microarrays</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genomic Instability</subject><subject>HeLa Cells</subject><subject>Homologous Recombination - genetics</subject><subject>Humans</subject><subject>Hyaluronan Receptors - metabolism</subject><subject>Informatics</subject><subject>Ki-67 Antigen - analysis</subject><subject>RNA, Small Interfering - genetics</subject><subject>Survival</subject><subject>Tumorigenesis</subject><issn>1541-7786</issn><issn>1557-3125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOwzAQRS0EoqXwCaDsYJPi8SOOFyCFiJcoQqpgbTmx0wblUeIExN-T0FLBhpVH9pmrGR-EjgFPAXh4DpyBL0QYTB_juQ_YxxzTHTQGzoVPgfDdod4wI3Tg3CvGBIMI9tGIQCAoBjJGFw_3UYQBg5dXrW102jrvI2-X3tU8jsDTlfEau-gK3VrnpbZqm9rVpfWqrkxsc4j2Ml04e7Q5J-jl5vo5vvNnT7f3cTTzUyZ56xOBCaMmyEQmMy0T3NeYYWM0NQlLrZRGGpqEmWHATai1CWVmOSMpSRPNNZ2gy3XuqktKa77n0IVaNXmpm09V61z9fanypVrU74oCF5zJPuB0E9DUb511rSpzl9qi0JWtO6fCkBFBBJCePPuXBBAQBlIy0aN8jab9p7jGZtuBAKtBkhoEqEGA6iUNt4Okvu_k9zbbrh8r9Ath941Z</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Kais, Zeina</creator><creator>Barsky, Sanford H</creator><creator>Mathsyaraja, Haritha</creator><creator>Zha, Alicia</creator><creator>Ransburgh, Derek J R</creator><creator>He, Gang</creator><creator>Pilarski, Robert T</creator><creator>Shapiro, Charles L</creator><creator>Huang, Kun</creator><creator>Parvin, Jeffrey D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110801</creationdate><title>KIAA0101 interacts with BRCA1 and regulates centrosome number</title><author>Kais, Zeina ; 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| subjects | biomarkers Biomarkers, Tumor - metabolism BRCA1 protein BRCA1 Protein - genetics BRCA1 Protein - metabolism BRCA2 protein Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Cell cycle Centrosome - metabolism Centrosomes DNA Damage DNA microarrays Extracellular Matrix Proteins - metabolism Female Gene Expression Regulation, Neoplastic Genomic Instability HeLa Cells Homologous Recombination - genetics Humans Hyaluronan Receptors - metabolism Informatics Ki-67 Antigen - analysis RNA, Small Interfering - genetics Survival Tumorigenesis |
| title | KIAA0101 interacts with BRCA1 and regulates centrosome number |
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