Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection

Production of auto‐antibodies against GCP‐2/CXCL6, GMCSF, IL‐17F, IL‐17E/IL‐25, TGF‐β1 and MMP‐9/gelatinase B. Anticytokine auto‐vaccination is a powerful tool for the study of cytokine functions in vivo but has remained rather esoteric as a result of numerous technical difficulties. We here describ...

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Veröffentlicht in:	Journal of leukocyte biology 2011-06, Vol.89 (6), p.1001-1007
Hauptverfasser:	Uyttenhove, Catherine, Marillier, Reece G., Tacchini‐Cottier, Fabienne, Charmoy, Mélanie, Caspi, Rachel R., Damsker, Jesse M., Goriely, Stanislas, Su, Dan, Van Damme, Jo, Struyf, Sofie, Opdenakker, Ghislain, Van Snick, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Animals antigen Cell Movement chemokine Chemokines - immunology cross‐linking Cytokines - immunology Glutaral - metabolism Immunization interleukin Interleukin-17 - physiology Leishmania major Leishmania major - immunology Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - parasitology Mice Mice, Inbred C57BL Mice, Knockout Microtubule-Associated Proteins - immunology Neutrophils Ovalbumin - immunology Protein Multimerization Technical Advance vaccine
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