Annexin 1 Released by Necrotic Human Glioblastoma Cells Stimulates Tumor Cell Growth through the Formyl Peptide Receptor 1

Highly malignant human gliomas overexpress the G-protein–coupled chemoattractant receptor formyl peptide receptor (FPR1), which promotes tumor progression when activated. Our previous studies demonstrated that necrotic glioblastoma cells release chemotactic agonist(s) that activate FPR1 on viable tu...

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Veröffentlicht in:	The American journal of pathology 2011-09, Vol.179 (3), p.1504-1512
Hauptverfasser:	Yang, Yan, Liu, Ying, Yao, Xiaohong, Ping, Yifang, Jiang, Tao, Liu, Qin, Xu, Senlin, Huang, Jian, Mou, Haiwei, Gong, Wanghua, Chen, Keqiang, Bian, Xiuwu, Ming Wang, Ji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A1 - metabolism Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Cell Transformation, Neoplastic Chemotaxis - physiology Gene Knockdown Techniques Glioblastoma - metabolism Glioblastoma - pathology Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Nude Necrosis Neoplasm Proteins - metabolism Neoplasm Transplantation Neurology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Formyl Peptide - agonists Regular Transplantation, Heterologous Tumors of the nervous system. Phacomatoses
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