Inhibition of Fas Ligand in NOD Mice Unmasks a Protective Role for IL-10 against Insulitis Development

Type 1 diabetes mellitus (T1D) is an autoimmune disease caused by the destruction of pancreatic insulin-producing β cells by autoreactive T cells early in life. Despite daily insulin injections, patients typically develop cardiovascular and other complications; and intensive efforts are being direct...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of pathology 2011-08, Vol.179 (2), p.725-732
Hauptverfasser:	Xiao, Zuoxiang, Mohamood, Abdiaziz S, Uddin, Sophia, Gutfreund, Rachel, Nakata, Chiaki, Marshall, Andrew, Kimura, Hiroaki, Caturegli, Patrizio, Womer, Karl L, Huang, Yanfei, Jie, Chunfa, Chakravarti, Shukti, Schneck, Jonathan P, Yagita, Hideo, Hamad, Abdel Rahim A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Proliferation Cell Separation Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fas Ligand Protein - metabolism Female Flow Cytometry Genotype Homozygote Immune System Insulin - metabolism Interleukin-10 - genetics Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Inbred NOD Mice, Transgenic Mutation Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regular T-Lymphocytes - cytology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!