Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1

Sprouting angiogenesis expands the embryonic vasculature enabling survival and homeostasis. Yet how the angiogenic capacity to form sprouts is allocated among endothelial cells (ECs) to guarantee the reproducible anatomy of stereotypical vascular beds remains unclear. Here we show that Sema-PlxnD1 s...

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Veröffentlicht in:	Developmental cell 2011-08, Vol.21 (2), p.301-314
Hauptverfasser:	Zygmunt, Tomasz, Gay, Carl Michael, Blondelle, Jordan, Singh, Manvendra K., Flaherty, Kathleen McCrone, Means, Paula Casey, Herwig, Lukas, Krudewig, Alice, Belting, Heinz-Georg, Affolter, Markus, Epstein, Jonathan A., Torres-Vázquez, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Animals, Genetically Modified Aorta - anatomy & histology Aorta - embryology Cell Movement - drug effects Cell Movement - genetics Cell Transplantation - physiology Embryo, Nonmammalian Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - physiology Endothelium - cytology Endothelium - embryology Endothelium - metabolism Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - genetics In Vitro Techniques Indoles - pharmacology Luminescent Proteins - genetics Molecular Sequence Data Neovascularization, Physiologic - genetics Neovascularization, Physiologic - physiology Oligodeoxyribonucleotides, Antisense - pharmacology Pyrroles - pharmacology Quinoxalines - pharmacology Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Notch - genetics Receptors, Notch - metabolism RNA, Messenger - metabolism Semaphorins - genetics Semaphorins - metabolism Signal Transduction - drug effects Signal Transduction - physiology Thiazolidinediones - pharmacology Vascular Endothelial Growth Factor Receptor-1 - deficiency Vascular Endothelial Growth Factor Receptor-1 - metabolism Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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