Nifedipine Affects the Course of Salmonella enterica Serovar Typhimurium Infection by Modulating Macrophage Iron Homeostasis

Background. Iron overload can adversely influence the course of infection by increasing microbial replication and suppressing antimicrobial immune effector pathways. Recently, we have shown that the calcium channel blocker nifedipine can mobilize tissue iron in mouse models of iron overload. We ther...

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Veröffentlicht in:	The Journal of infectious diseases 2011-09, Vol.204 (5), p.685-694
Hauptverfasser:	Mair, Sabine M., Nairz, Manfred, Bellmann-Weiler, Rosa, Muehlbacher, Thomas, Schroll, Andrea, Theurl, Igor, Moser, Patrizia L., Talasz, Heribert, Fang, Ferric C., Weiss, Guenter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacterial Load - drug effects Bacteriology Biological and medical sciences Calcium Channel Blockers - pharmacology Cation Transport Proteins - metabolism Cell Line Chlamydophila Infections Chlamydophila pneumoniae - drug effects Chlamydophila pneumoniae - growth & development Cytokines - metabolism Ferritins - metabolism Fundamental and applied biological sciences. Psychology Human bacterial diseases Infections Infectious diseases Iron Iron - metabolism Liver - metabolism Liver - microbiology Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - microbiology Major and Brief Reports Male Medical sciences Mice Mice, Inbred C57BL Microbiology Miscellaneous Nifedipine - pharmacology Nifedipine - therapeutic use Pathogens RNA, Messenger - metabolism Salmonella Salmonella enterica Salmonella Infections, Animal - drug therapy Salmonella Infections, Animal - metabolism Salmonella Infections, Animal - microbiology Salmonella typhimurium - drug effects Salmonella typhimurium - growth & development Solvents Spleen Spleen - metabolism Spleen - microbiology
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