Steric effects on the enantiodiscrimination of diproline chiral stationary phases in the resolution of racemic compounds

Eight diproline chiral stationary phases with different end-capping groups were prepared and evaluated for the enantio-selective resolution of 41 racemic analytes. The end-capping group on the N-terminal of the peptide proved to be important as the chiral separation efficiency was decreased signific...

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Veröffentlicht in:Journal of Chromatography A 2011-08, Vol.1218 (32), p.5498-5503
Hauptverfasser: Dai, Zhi, Ye, Guozhong, Pittman, Charles U., Li, Tingyu
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Sprache:eng
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