Overexpression of secreted frizzled‐related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects

Secreted frizzled‐related protein 1 (sFRP1) is an antagonist of Wnt signaling, an important pathway in maintaining bone homeostasis. In this study we evaluated the skeletal phenotype of mice overexpressing sFRP1 (sFRP1 Tg) and the interaction of parathyroid hormone (PTH) treatment and sFRP1 (over)ex...

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Veröffentlicht in:	Journal of bone and mineral research 2010-02, Vol.25 (2), p.190-199
Hauptverfasser:	Yao, Wei, Cheng, Zhiqiang, Shahnazari, Mohammad, Dai, Wewei, Johnson, Mark L, Lane, Nancy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western bone mass Bone Resorption Cell Differentiation - drug effects Cells, Cultured Female Fundamental and applied biological sciences. Psychology Gene Expression Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Transgenic Original Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteogenesis - physiology Parathyroid Hormone - pharmacology PTH Reverse Transcriptase Polymerase Chain Reaction sex difference SFRP1 Signal Transduction Skeleton and joints transgenic Vertebrates: osteoarticular system, musculoskeletal system
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