DMP1 C‐terminal mutant mice recapture the human ARHR tooth phenotype

DMP1 mutations in autosomal recessive hypophosphatemic rickets (ARHR) patients and mice lacking Dmp1 display an overlapping pathophysiology, such as hypophosphatemia. However, subtle differences exist between the mouse model and human ARHR patients. These differences could be due to a species specif...

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Veröffentlicht in:	Journal of bone and mineral research 2010-10, Vol.25 (10), p.2155-2164
Hauptverfasser:	Jiang, Baichun, Cao, Zhengguo, Lu, Yongbo, Janik, Carol, Lauziere, Stephanie, Xie, Yixia, Poliard, Anne, Qin, Chunlin, Ward, Leanne M, Feng, Jian Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARHR Base Sequence Biological and medical sciences Disease Models, Animal DMP1 DNA Primers Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - physiology Familial Hypophosphatemic Rickets - genetics Familial Hypophosphatemic Rickets - pathology FGF‐23 Fundamental and applied biological sciences. Psychology Humans hypophosphatemia In Situ Hybridization Mice Mice, Mutant Strains odontoblast Original Phenotype Reverse Transcriptase Polymerase Chain Reaction Skeleton and joints Tomography, X-Ray Computed Tooth - diagnostic imaging Tooth - pathology Transgenes Vertebrates: osteoarticular system, musculoskeletal system
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