Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification

The NOTCH signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. However, the molecular basis for its role at the different steps of stem cell lineage commitment is unclear. We recently identified the NOTCH signaling pathway as a positive regulato...

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Veröffentlicht in:	Blood 2011-08, Vol.118 (5), p.1264-1273
Hauptverfasser:	Cornejo, Melanie G., Mabialah, Vinciane, Sykes, Stephen M., Khandan, Tulasi, Lo Celso, Cristina, Lopez, Cécile K., Rivera-Muñoz, Paola, Rameau, Philippe, Tothova, Zuzana, Aster, Jon C., DePinho, Ronald A., Scadden, David T., Gilliland, D. Gary, Mercher, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Differentiation - genetics Cell Differentiation - physiology Cell Lineage - genetics Cell Lineage - physiology Cells, Cultured Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Forkhead Transcription Factors - physiology Hematologic and hematopoietic diseases Hematopoiesis and Stem Cells Medical sciences Megakaryocytes - metabolism Megakaryocytes - physiology Mice Mice, Inbred C57BL Mice, Transgenic Oncogene Protein v-akt - genetics Oncogene Protein v-akt - metabolism Oncogene Protein v-akt - physiology Platelets and Thrombopoiesis PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN Phosphohydrolase - physiology Receptor Cross-Talk - physiology Receptors, Notch - genetics Receptors, Notch - metabolism Receptors, Notch - physiology Signal Transduction - genetics Signal Transduction - physiology Thrombopoiesis - genetics
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