Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles

5′- and 3′-untranslated regions (UTRs) are important regulators of gene expression and play key roles in disease progression and susceptibility. The 5′-UTR of the fragile X mental retardation 1 (FMR1) gene contains a CGG repeat element that is expanded (>200 CGG repeats; full mutation) and methyl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nucleic acids research 2011-08, Vol.39 (14), p.6172-6185
Hauptverfasser:	Tassone, Flora, De Rubeis, Silvia, Carosi, Chiara, La Fata, Giorgio, Serpa, Gisele, Raske, Christopher, Willemsen, Rob, Hagerman, Paul J., Bagni, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 5' Untranslated Regions Alleles Animals Base Sequence Brain - metabolism Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - metabolism Humans Mice Molecular Sequence Data Mutation Polyadenylation RNA Transcription Initiation Site Trinucleotide Repeats Untranslated Regions
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!