Are poor responders patients at higher risk for producing aneuploid embryos in vitro?
Purpose To test the hypothesis that aged women with poor ovarian response express an increase on embryo chromosomal alterations when compared to aged women who presented normal response. Methods Couples undergoing intracytoplasmic sperm injection cycles with preimplantation genetic screening, were s...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2011-05, Vol.28 (5), p.399-404 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | Setti, Amanda Souza Braga, Daniela Paes de Almeida Ferreira Figueira, Rita de Cássia Savio Azevedo, Matheus de Castro Iaconelli, Assumpto Borges, Edson |
| description | Purpose
To test the hypothesis that aged women with poor ovarian response express an increase on embryo chromosomal alterations when compared to aged women who presented normal response.
Methods
Couples undergoing intracytoplasmic sperm injection cycles with preimplantation genetic screening, were subdivided into two groups: Poor Responder group (
n
= 34), patients who produced ≤4 oocytes; and Normoresponder group (
n
= 50), patients who produced ≥5 oocytes. Groups were compared regarding cycles’ outcomes and aneuploidy frequency.
Results
There were no significant differences between and groups regarding the fertilization rate (
p
= 0.6861), clinical pregnancy (
p
= 0.9208), implantation (
p
= 0.6863), miscarriage (
p
= 0.6788) and the percentage of aneuploid embryos (
p
= 0.270). Embryo transfer rate was significantly lower on poor responder group (
p
= 0.0128) and logistic regression confirmed the influence of poor response on the chance of embryo transfer (
p
= 0.016).
Conclusions
Aged females responding poorly to gonadotrophins are not at a higher risk for producing aneuploid embryos in vitro. |
| doi_str_mv | 10.1007/s10815-010-9516-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3151354</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2418337911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c500t-88155758db2dfacde6de78d09e48a4eaf7a7fc191fe8a05fb03f96becb4469763</originalsourceid><addsrcrecordid>eNqNkc1rFTEUxYMotlb_ADcS3LgavZlMvjZKKX5BwY1dh8zk5r3UeZMxmSn0vzfDq_UDBFcJ3F_OPSeHkOcMXjMA9aYw0Ew0wKAxgsmmfUBOmVC8UZzDw3oHoRvopD4hT0q5BgCjW_6YnLSMbQLmlFydZ6RzSplmLHOaPOZCZ7dEnJZC3UL3cbfHOo3lGw0Vm3Py6xCnHXUTrvOYoqd46PNtKjRO9CYuOb17Sh4FNxZ8dneekasP779efGouv3z8fHF-2QwCYGl0dS-U0L5vfXCDR-lRaQ8GO-06dEE5FQZmWEDtQIQeeDCyx6HvOmmU5Gfk7VF3XvsD-qGazm60c44Hl29tctH-OZni3u7SjeVMMC66KvDqTiCn7yuWxR5iGXAca7i0FquNYZ1WrP0PkrdStkJX8uVf5HVa81T_wdbAdavkm3N2hIacSskY7k0zsFs39liureXarVy7WXjxe9r7Fz_brEB7BEodTTvMvzb_W_UHmlmxKQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>881354636</pqid></control><display><type>article</type><title>Are poor responders patients at higher risk for producing aneuploid embryos in vitro?</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Setti, Amanda Souza ; Braga, Daniela Paes de Almeida Ferreira ; Figueira, Rita de Cássia Savio ; Azevedo, Matheus de Castro ; Iaconelli, Assumpto ; Borges, Edson</creator><creatorcontrib>Setti, Amanda Souza ; Braga, Daniela Paes de Almeida Ferreira ; Figueira, Rita de Cássia Savio ; Azevedo, Matheus de Castro ; Iaconelli, Assumpto ; Borges, Edson</creatorcontrib><description>Purpose
To test the hypothesis that aged women with poor ovarian response express an increase on embryo chromosomal alterations when compared to aged women who presented normal response.
Methods
Couples undergoing intracytoplasmic sperm injection cycles with preimplantation genetic screening, were subdivided into two groups: Poor Responder group (
n
= 34), patients who produced ≤4 oocytes; and Normoresponder group (
n
= 50), patients who produced ≥5 oocytes. Groups were compared regarding cycles’ outcomes and aneuploidy frequency.
Results
There were no significant differences between and groups regarding the fertilization rate (
p
= 0.6861), clinical pregnancy (
p
= 0.9208), implantation (
p
= 0.6863), miscarriage (
p
= 0.6788) and the percentage of aneuploid embryos (
p
= 0.270). Embryo transfer rate was significantly lower on poor responder group (
p
= 0.0128) and logistic regression confirmed the influence of poor response on the chance of embryo transfer (
p
= 0.016).
Conclusions
Aged females responding poorly to gonadotrophins are not at a higher risk for producing aneuploid embryos in vitro.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-010-9516-2</identifier><identifier>PMID: 21110079</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Age ; Age Factors ; Aneuploidy ; Assisted Reproduction Technologies ; Embryo Implantation ; Embryo Transfer ; Embryos ; Female ; Fertility ; Gynecology ; Human Genetics ; Humans ; In Situ Hybridization, Fluorescence ; In vitro fertilization ; Lasers ; Male ; Medicine ; Medicine & Public Health ; Mineral oils ; Oocytes - cytology ; Ovaries ; Pregnancy ; Pregnancy Rate ; Reproductive Medicine ; Reproductive technologies ; Sperm ; Sperm Injections, Intracytoplasmic</subject><ispartof>Journal of assisted reproduction and genetics, 2011-05, Vol.28 (5), p.399-404</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-88155758db2dfacde6de78d09e48a4eaf7a7fc191fe8a05fb03f96becb4469763</citedby><cites>FETCH-LOGICAL-c500t-88155758db2dfacde6de78d09e48a4eaf7a7fc191fe8a05fb03f96becb4469763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151354/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151354/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21110079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Setti, Amanda Souza</creatorcontrib><creatorcontrib>Braga, Daniela Paes de Almeida Ferreira</creatorcontrib><creatorcontrib>Figueira, Rita de Cássia Savio</creatorcontrib><creatorcontrib>Azevedo, Matheus de Castro</creatorcontrib><creatorcontrib>Iaconelli, Assumpto</creatorcontrib><creatorcontrib>Borges, Edson</creatorcontrib><title>Are poor responders patients at higher risk for producing aneuploid embryos in vitro?</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
To test the hypothesis that aged women with poor ovarian response express an increase on embryo chromosomal alterations when compared to aged women who presented normal response.
Methods
Couples undergoing intracytoplasmic sperm injection cycles with preimplantation genetic screening, were subdivided into two groups: Poor Responder group (
n
= 34), patients who produced ≤4 oocytes; and Normoresponder group (
n
= 50), patients who produced ≥5 oocytes. Groups were compared regarding cycles’ outcomes and aneuploidy frequency.
Results
There were no significant differences between and groups regarding the fertilization rate (
p
= 0.6861), clinical pregnancy (
p
= 0.9208), implantation (
p
= 0.6863), miscarriage (
p
= 0.6788) and the percentage of aneuploid embryos (
p
= 0.270). Embryo transfer rate was significantly lower on poor responder group (
p
= 0.0128) and logistic regression confirmed the influence of poor response on the chance of embryo transfer (
p
= 0.016).
Conclusions
Aged females responding poorly to gonadotrophins are not at a higher risk for producing aneuploid embryos in vitro.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aneuploidy</subject><subject>Assisted Reproduction Technologies</subject><subject>Embryo Implantation</subject><subject>Embryo Transfer</subject><subject>Embryos</subject><subject>Female</subject><subject>Fertility</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>In vitro fertilization</subject><subject>Lasers</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mineral oils</subject><subject>Oocytes - cytology</subject><subject>Ovaries</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Reproductive Medicine</subject><subject>Reproductive technologies</subject><subject>Sperm</subject><subject>Sperm Injections, Intracytoplasmic</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1rFTEUxYMotlb_ADcS3LgavZlMvjZKKX5BwY1dh8zk5r3UeZMxmSn0vzfDq_UDBFcJ3F_OPSeHkOcMXjMA9aYw0Ew0wKAxgsmmfUBOmVC8UZzDw3oHoRvopD4hT0q5BgCjW_6YnLSMbQLmlFydZ6RzSplmLHOaPOZCZ7dEnJZC3UL3cbfHOo3lGw0Vm3Py6xCnHXUTrvOYoqd46PNtKjRO9CYuOb17Sh4FNxZ8dneekasP779efGouv3z8fHF-2QwCYGl0dS-U0L5vfXCDR-lRaQ8GO-06dEE5FQZmWEDtQIQeeDCyx6HvOmmU5Gfk7VF3XvsD-qGazm60c44Hl29tctH-OZni3u7SjeVMMC66KvDqTiCn7yuWxR5iGXAca7i0FquNYZ1WrP0PkrdStkJX8uVf5HVa81T_wdbAdavkm3N2hIacSskY7k0zsFs39liureXarVy7WXjxe9r7Fz_brEB7BEodTTvMvzb_W_UHmlmxKQ</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Setti, Amanda Souza</creator><creator>Braga, Daniela Paes de Almeida Ferreira</creator><creator>Figueira, Rita de Cássia Savio</creator><creator>Azevedo, Matheus de Castro</creator><creator>Iaconelli, Assumpto</creator><creator>Borges, Edson</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110501</creationdate><title>Are poor responders patients at higher risk for producing aneuploid embryos in vitro?</title><author>Setti, Amanda Souza ; Braga, Daniela Paes de Almeida Ferreira ; Figueira, Rita de Cássia Savio ; Azevedo, Matheus de Castro ; Iaconelli, Assumpto ; Borges, Edson</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-88155758db2dfacde6de78d09e48a4eaf7a7fc191fe8a05fb03f96becb4469763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aneuploidy</topic><topic>Assisted Reproduction Technologies</topic><topic>Embryo Implantation</topic><topic>Embryo Transfer</topic><topic>Embryos</topic><topic>Female</topic><topic>Fertility</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>In vitro fertilization</topic><topic>Lasers</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mineral oils</topic><topic>Oocytes - cytology</topic><topic>Ovaries</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Reproductive Medicine</topic><topic>Reproductive technologies</topic><topic>Sperm</topic><topic>Sperm Injections, Intracytoplasmic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Setti, Amanda Souza</creatorcontrib><creatorcontrib>Braga, Daniela Paes de Almeida Ferreira</creatorcontrib><creatorcontrib>Figueira, Rita de Cássia Savio</creatorcontrib><creatorcontrib>Azevedo, Matheus de Castro</creatorcontrib><creatorcontrib>Iaconelli, Assumpto</creatorcontrib><creatorcontrib>Borges, Edson</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Setti, Amanda Souza</au><au>Braga, Daniela Paes de Almeida Ferreira</au><au>Figueira, Rita de Cássia Savio</au><au>Azevedo, Matheus de Castro</au><au>Iaconelli, Assumpto</au><au>Borges, Edson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are poor responders patients at higher risk for producing aneuploid embryos in vitro?</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>28</volume><issue>5</issue><spage>399</spage><epage>404</epage><pages>399-404</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
To test the hypothesis that aged women with poor ovarian response express an increase on embryo chromosomal alterations when compared to aged women who presented normal response.
Methods
Couples undergoing intracytoplasmic sperm injection cycles with preimplantation genetic screening, were subdivided into two groups: Poor Responder group (
n
= 34), patients who produced ≤4 oocytes; and Normoresponder group (
n
= 50), patients who produced ≥5 oocytes. Groups were compared regarding cycles’ outcomes and aneuploidy frequency.
Results
There were no significant differences between and groups regarding the fertilization rate (
p
= 0.6861), clinical pregnancy (
p
= 0.9208), implantation (
p
= 0.6863), miscarriage (
p
= 0.6788) and the percentage of aneuploid embryos (
p
= 0.270). Embryo transfer rate was significantly lower on poor responder group (
p
= 0.0128) and logistic regression confirmed the influence of poor response on the chance of embryo transfer (
p
= 0.016).
Conclusions
Aged females responding poorly to gonadotrophins are not at a higher risk for producing aneuploid embryos in vitro.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21110079</pmid><doi>10.1007/s10815-010-9516-2</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-0468 |
| ispartof | Journal of assisted reproduction and genetics, 2011-05, Vol.28 (5), p.399-404 |
| issn | 1058-0468 1573-7330 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3151354 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Age Age Factors Aneuploidy Assisted Reproduction Technologies Embryo Implantation Embryo Transfer Embryos Female Fertility Gynecology Human Genetics Humans In Situ Hybridization, Fluorescence In vitro fertilization Lasers Male Medicine Medicine & Public Health Mineral oils Oocytes - cytology Ovaries Pregnancy Pregnancy Rate Reproductive Medicine Reproductive technologies Sperm Sperm Injections, Intracytoplasmic |
| title | Are poor responders patients at higher risk for producing aneuploid embryos in vitro? |
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