Innate immunity and coagulation
Infection frequently elicits a coagulation response. Endotoxin triggers the formation of tissue factor initiating coagulation, down regulates anticoagulant mechanisms including the protein C pathway and heparin‐like proteoglycans and up regulates plasminogen activator inhibitor. The overall physiolo...
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| Veröffentlicht in: | Journal of thrombosis and haemostasis 2011-07, Vol.9 (Suppl 1), p.182-188 |
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| container_end_page | 188 |
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| container_issue | Suppl 1 |
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| container_title | Journal of thrombosis and haemostasis |
| container_volume | 9 |
| creator | ESMON, C. T. XU, J. LUPU, F. |
| description | Infection frequently elicits a coagulation response. Endotoxin triggers the formation of tissue factor initiating coagulation, down regulates anticoagulant mechanisms including the protein C pathway and heparin‐like proteoglycans and up regulates plasminogen activator inhibitor. The overall physiological result of this is to promote coagulation through enhancing initiation, suppressing negative regulation and impairing fibrin removal. The response to infection also leads to tissue destruction. Nucleosomes and histones released from the injured cells trigger further inflammation, protection from the pathogen but further tissue injury leading to multi‐organ failure. Such a complex response to infection presumably arises due to the role of coagulation in the control and clearance of the infectious agent. |
| doi_str_mv | 10.1111/j.1538-7836.2011.04323.x |
| format | Article |
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T.</creatorcontrib><creatorcontrib>XU, J.</creatorcontrib><creatorcontrib>LUPU, F.</creatorcontrib><title>Innate immunity and coagulation</title><title>Journal of thrombosis and haemostasis</title><addtitle>J Thromb Haemost</addtitle><description>Infection frequently elicits a coagulation response. Endotoxin triggers the formation of tissue factor initiating coagulation, down regulates anticoagulant mechanisms including the protein C pathway and heparin‐like proteoglycans and up regulates plasminogen activator inhibitor. The overall physiological result of this is to promote coagulation through enhancing initiation, suppressing negative regulation and impairing fibrin removal. The response to infection also leads to tissue destruction. Nucleosomes and histones released from the injured cells trigger further inflammation, protection from the pathogen but further tissue injury leading to multi‐organ failure. Such a complex response to infection presumably arises due to the role of coagulation in the control and clearance of the infectious agent.</description><subject>Blood Coagulation</subject><subject>Complement Activation</subject><subject>histones</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>innate immunity</subject><subject>natural anticoagulants</subject><subject>nucleosomes</subject><subject>protein C</subject><subject>thrombosis</subject><issn>1538-7933</issn><issn>1538-7836</issn><issn>1538-7836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9PwzAMxSMEYmPwFaA3Ti1xkjbpASQ0ARuaxGWcIzdLR6f-GU0L27enZWOCG77Y0nt-tn6EeEAD6OpmFUDIlS8VjwJGAQIqOOPB5ogMD8LxzxxzPiBnzq0ohThk9JQMGEgFLBRDcjUtS2yslxVFW2bN1sNy4ZkKl22OTVaV5-QkxdzZi30fkdfHh_l44s9enqbj-5lvhOTcN1ZBilEMqaKxAB4CCstEkjDJOJoUcSEQJJNRIiVylcYppdYYZEYxKSgfkbtd7rpNCrswtmxqzPW6zgqst7rCTP9VyuxNL6sPzSHsiPQB1_uAunpvrWt0kTlj8xxLW7VOKwWUCohE51Q7p6kr52qbHq4A1T1evdI9Od1T1D1e_Y1Xb7rVy99fHhZ_eHaG253hM8vt9t_B-nk-6Sf-BYQwiKQ</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>ESMON, C. 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T. ; XU, J. ; LUPU, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4733-ce81fa691f80941351a4e24bb2723acfaad4a17276b77a38f9f00ecca2c827403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Blood Coagulation</topic><topic>Complement Activation</topic><topic>histones</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>innate immunity</topic><topic>natural anticoagulants</topic><topic>nucleosomes</topic><topic>protein C</topic><topic>thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ESMON, C. T.</creatorcontrib><creatorcontrib>XU, J.</creatorcontrib><creatorcontrib>LUPU, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ESMON, C. 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| fulltext | fulltext |
| identifier | ISSN: 1538-7933 |
| ispartof | Journal of thrombosis and haemostasis, 2011-07, Vol.9 (Suppl 1), p.182-188 |
| issn | 1538-7933 1538-7836 1538-7836 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Blood Coagulation Complement Activation histones Humans Immunity, Innate innate immunity natural anticoagulants nucleosomes protein C thrombosis |
| title | Innate immunity and coagulation |
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