A prospective study of trans fat intake and risk of preeclampsia in Denmark

Background/Objectives: An association between biomarkers of trans fat intake and greater risk of preeclampsia has been reported, but research in this area is scant. Thus, we examined the association of second trimester intake of trans fats with risk of preeclampsia and severe preeclampsia. Subjects/...

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Veröffentlicht in:European journal of clinical nutrition 2011-08, Vol.65 (8), p.944-951
Hauptverfasser: Chavarro, J E, Halldorsson, T I, Leth, T, Bysted, A, Olsen, S F
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container_issue 8
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container_title European journal of clinical nutrition
container_volume 65
creator Chavarro, J E
Halldorsson, T I
Leth, T
Bysted, A
Olsen, S F
description Background/Objectives: An association between biomarkers of trans fat intake and greater risk of preeclampsia has been reported, but research in this area is scant. Thus, we examined the association of second trimester intake of trans fats with risk of preeclampsia and severe preeclampsia. Subjects/Methods: We followed 67 186 pregnancies of women participating in the Danish National Birth Cohort between 1998 and 2003. Diet was assessed with a food frequency questionnaire at gestation week 25, and preeclampsia diagnosis was obtained by linkage with the Danish National Patient Registry. Results: There were 1804 cases of preeclampsia and 402 cases of severe preeclampsia identified in the cohort. Intake of trans fats decreased during the study period as a consequence of a reduction in industrial trans fat intake. Second trimester intake of trans fats was unrelated to risk of preeclampsia or severe preeclampsia. The relative risk (95% confidence interval; P , trend) of preeclampsia and severe preeclampsia comparing top to bottom quintiles of trans fat intake were 0.95(0.81; 1.11, 0.33) and 1.07 (0.78; 1.48, 0.92), respectively. Conclusion: Second trimester intake of trans fats is unrelated to risk of preeclampsia within the intake range observed in a period of gradual reduction of industrial trans fats from the Danish food supply.
doi_str_mv 10.1038/ejcn.2011.66
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Thus, we examined the association of second trimester intake of trans fats with risk of preeclampsia and severe preeclampsia. Subjects/Methods: We followed 67 186 pregnancies of women participating in the Danish National Birth Cohort between 1998 and 2003. Diet was assessed with a food frequency questionnaire at gestation week 25, and preeclampsia diagnosis was obtained by linkage with the Danish National Patient Registry. Results: There were 1804 cases of preeclampsia and 402 cases of severe preeclampsia identified in the cohort. Intake of trans fats decreased during the study period as a consequence of a reduction in industrial trans fat intake. Second trimester intake of trans fats was unrelated to risk of preeclampsia or severe preeclampsia. The relative risk (95% confidence interval; P , trend) of preeclampsia and severe preeclampsia comparing top to bottom quintiles of trans fat intake were 0.95(0.81; 1.11, 0.33) and 1.07 (0.78; 1.48, 0.92), respectively. 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subjects 631/45/287/1182
692/699/75/243/793
692/700/478/174
Adult
Biological and medical sciences
Biomarkers
Clinical Nutrition
Confidence intervals
Denmark - epidemiology
Diet
Dietary Fats - administration & dosage
Dietary Fats - adverse effects
Diseases of mother, fetus and pregnancy
Epidemiology
Fats
Feeding. Feeding behavior
Female
Food
Food Supply
Fundamental and applied biological sciences. Psychology
Gynecology. Andrology. Obstetrics
Health aspects
Humans
Internal Medicine
Interviews as Topic
Logistic Models
Maternal Nutritional Physiological Phenomena
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Multivariate Analysis
Nutrition Assessment
Oils & fats
original-article
Pre-eclampsia
Pre-Eclampsia - epidemiology
Pre-Eclampsia - etiology
Preeclampsia
Pregnancy
Pregnancy. Fetus. Placenta
Prospective Studies
Public Health
Reduction
Risk
Risk Factors
Surveys and Questionnaires
Trans fats
Trans fatty acids
Trans Fatty Acids - administration & dosage
Trans Fatty Acids - adverse effects
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Young Adult
title A prospective study of trans fat intake and risk of preeclampsia in Denmark
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