Kappa Opioid Receptor Signaling in the Basolateral Amygdala Regulates Conditioned Fear and Anxiety in Rats

Background The kappa opioid receptor (KOR) system contributes to the prodepressive and aversive consequences of stress and is implicated in the facilitation of conditioned fear and anxiety in rodents. Here, we sought to identify neural circuits that mediate KOR system effects on fear and anxiety in...

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Veröffentlicht in:	Biological psychiatry (1969) 2011-09, Vol.70 (5), p.425-433
Hauptverfasser:	Knoll, Allison T, Muschamp, John W, Sillivan, Stephanie E, Ferguson, Deveroux, Dietz, David M, Meloni, Edward G, Carroll, F. Ivy, Nestler, Eric J, Konradi, Christine, Carlezon, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - drug effects Amygdala - metabolism Animals Anxiety Anxiety - metabolism conditioned fear Conditioning, Psychological - drug effects Conditioning, Psychological - physiology Corpus Striatum - drug effects Corpus Striatum - metabolism Disease Models, Animal Dynorphins - physiology elevated plus maze Extinction, Psychological - physiology Fear - drug effects Fear - physiology fear-potentiated startle Gene Expression Regulation - physiology Hippocampus - drug effects Hippocampus - metabolism JDTic Male Maze Learning - drug effects Maze Learning - physiology Microinjections Piperidines - administration & dosage Piperidines - pharmacology Psychiatry quantitative PCR Rats Receptors, Opioid, kappa - antagonists & inhibitors Receptors, Opioid, kappa - biosynthesis Receptors, Opioid, kappa - physiology Reflex, Startle - drug effects Reflex, Startle - physiology Signal Transduction - drug effects Signal Transduction - physiology Tetrahydroisoquinolines - administration & dosage Tetrahydroisoquinolines - pharmacology
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