An optogenetic toolbox designed for primates

Here the authors describe a set of new optogenetic tools for use in primates that are meant to address the unique constraints of working with this species. They characterize opsin expression, the reliability of optogenetic stimulation and its effect on behavior, and methods for determining localizat...

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Veröffentlicht in:	Nature neuroscience 2011-03, Vol.14 (3), p.387-397
Hauptverfasser:	Diester, Ilka, Kaufman, Matthew T, Mogri, Murtaza, Pashaie, Ramin, Goo, Werapong, Yizhar, Ofer, Ramakrishnan, Charu, Deisseroth, Karl, Shenoy, Krishna V
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2253 631/378 631/378/557 Analysis Animal Genetics and Genomics Animals Behavior Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain stimulation Computer engineering Dependovirus - genetics Dependovirus - metabolism Electrical engineering Experiments Gene Transfer Techniques Genetic aspects Genetic Vectors - genetics Genetic Vectors - metabolism Humans Lentivirus - genetics Lentivirus - metabolism Light Macaca mulatta - anatomy & histology Macaca mulatta - genetics Macaca mulatta - physiology Monkeys & apes Motor cortex Neurobiology Neurons Neurosciences Opsins Opsins - genetics Opsins - metabolism Photic Stimulation - methods Physiological aspects Primates Primates - anatomy & histology Primates - genetics Primates - physiology Promoter Regions, Genetic Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Synapsins - genetics Synapsins - metabolism technical-report Vectors (Biology)
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