Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials
[Display omitted] ► In this review, we will first summarize key methodologies used to manipulate the surface of living mammalian cells with synthetic material. ► We will then discuss the main challenges to overcome to stably modify cell surfaces and we will highlight how these cell modifications can...
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| Veröffentlicht in: | Nano today 2011-06, Vol.6 (3), p.309-325 |
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| creator | Stephan, Matthias T. Irvine, Darrell J. |
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► In this review, we will first summarize key methodologies used to manipulate the surface of living mammalian cells with synthetic material. ► We will then discuss the main challenges to overcome to stably modify cell surfaces and we will highlight how these cell modifications can be applied to enhance the therapeutic potential of cell products in clinic. ► Finally, we will outline future trends and perspectives of this relatively new and fast-developing discipline.
Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells. |
| doi_str_mv | 10.1016/j.nantod.2011.04.001 |
| format | Article |
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► In this review, we will first summarize key methodologies used to manipulate the surface of living mammalian cells with synthetic material. ► We will then discuss the main challenges to overcome to stably modify cell surfaces and we will highlight how these cell modifications can be applied to enhance the therapeutic potential of cell products in clinic. ► Finally, we will outline future trends and perspectives of this relatively new and fast-developing discipline.
Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.</description><identifier>ISSN: 1748-0132</identifier><identifier>EISSN: 1878-044X</identifier><identifier>DOI: 10.1016/j.nantod.2011.04.001</identifier><identifier>PMID: 21826117</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adoptive T cell therapy ; Cell surface bioengineering ; Cell therapy ; Nanoparticles</subject><ispartof>Nano today, 2011-06, Vol.6 (3), p.309-325</ispartof><rights>2011 Elsevier Ltd</rights><rights>2011 Elsevier Ltd. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-eeda8489166db3118f8286d207dde3a8943ed20397fc5bbce30818a8684e58b33</citedby><cites>FETCH-LOGICAL-c529t-eeda8489166db3118f8286d207dde3a8943ed20397fc5bbce30818a8684e58b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1748013211000429$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21826117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stephan, Matthias T.</creatorcontrib><creatorcontrib>Irvine, Darrell J.</creatorcontrib><title>Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials</title><title>Nano today</title><addtitle>Nano Today</addtitle><description>[Display omitted]
► In this review, we will first summarize key methodologies used to manipulate the surface of living mammalian cells with synthetic material. ► We will then discuss the main challenges to overcome to stably modify cell surfaces and we will highlight how these cell modifications can be applied to enhance the therapeutic potential of cell products in clinic. ► Finally, we will outline future trends and perspectives of this relatively new and fast-developing discipline.
Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.</description><subject>Adoptive T cell therapy</subject><subject>Cell surface bioengineering</subject><subject>Cell therapy</subject><subject>Nanoparticles</subject><issn>1748-0132</issn><issn>1878-044X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9UU1r3DAQFaUhSdP8g1J87GVdjSXbsz0UypJ-QCCXFnoTsjTe1bKWtpIcyL-PzKZpe-lFM8O892Y0j7E3wGvg0L3f1177HGzdcICay5pzeMEuAXtccSl_vix5L0sOorlgr1Lacy7bXrbn7KIBbDqA_pLZG7_T3ji_rQwdDlXeUdRHR6kaY5iWsgpzTs5S5fyHarNg0hxHbagiv3WeKC7kOS1vevCFkZ2pym5h0rk09SG9ZmdjCXT9FK_Yj8833zdfV7d3X75tPt2uTNus84rIapS4hq6zgwDAERvsbMN7a0loXEtBpRLrfjTtMBgSHAE1diipxUGIK_bxpHuch4msIZ-jPqhjdJOODypop_7teLdT23CvBEjs2r4IvHsSiOHXTCmryaXlLtpTmJMCFK3skfMFKk9QE0NKkcbnMcDVYpDaq5NBajFIcamKQYX29u8Vn0m_HfnzByqHuncUVTKOvCHrIpmsbHD_n_AI_dOmcA</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Stephan, Matthias T.</creator><creator>Irvine, Darrell J.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110601</creationdate><title>Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials</title><author>Stephan, Matthias T. ; Irvine, Darrell J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-eeda8489166db3118f8286d207dde3a8943ed20397fc5bbce30818a8684e58b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adoptive T cell therapy</topic><topic>Cell surface bioengineering</topic><topic>Cell therapy</topic><topic>Nanoparticles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stephan, Matthias T.</creatorcontrib><creatorcontrib>Irvine, Darrell J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nano today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stephan, Matthias T.</au><au>Irvine, Darrell J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials</atitle><jtitle>Nano today</jtitle><addtitle>Nano Today</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>6</volume><issue>3</issue><spage>309</spage><epage>325</epage><pages>309-325</pages><issn>1748-0132</issn><eissn>1878-044X</eissn><abstract>[Display omitted]
► In this review, we will first summarize key methodologies used to manipulate the surface of living mammalian cells with synthetic material. ► We will then discuss the main challenges to overcome to stably modify cell surfaces and we will highlight how these cell modifications can be applied to enhance the therapeutic potential of cell products in clinic. ► Finally, we will outline future trends and perspectives of this relatively new and fast-developing discipline.
Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>21826117</pmid><doi>10.1016/j.nantod.2011.04.001</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nano today, 2011-06, Vol.6 (3), p.309-325 |
| issn | 1748-0132 1878-044X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3148657 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Adoptive T cell therapy Cell surface bioengineering Cell therapy Nanoparticles |
| title | Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials |
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