Synthesis of Folate-Functionalized RAFT Polymers for Targeted siRNA Delivery

Receptor-mediated, cell-specific delivery of siRNA enables silencing of target genes in specific tissues, opening the door to powerful therapeutic options for a multitude of diseases. However, the development of delivery systems capable of targeted and effective siRNA delivery typically requires mul...

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Veröffentlicht in:	Biomacromolecules 2011-07, Vol.12 (7), p.2708-2714
Hauptverfasser:	Benoit, Danielle S. W, Srinivasan, Selvi, Shubin, Andrew D, Stayton, Patrick S
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Biological and medical sciences Cancer Drug Delivery Systems Exact sciences and technology Folate Receptors, GPI-Anchored - antagonists & inhibitors Folate Receptors, GPI-Anchored - genetics Folic Acid - chemistry General pharmacology HeLa Cells Humans Medical sciences Molecular Structure Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymerization Polymers - chemical synthesis Polymers - chemistry Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts RNA, Small Interfering - chemistry RNA, Small Interfering - pharmacology Stereoisomerism Tumor Cells, Cultured
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