The Glucoamylase Inhibitor Acarbose Is a Direct Activator of Phosphorylase Kinase

Phosphorylase kinase (PhK), an (αβγδ)4 complex, stimulates energy production from glycogen in the cascade activation of glycogenolysis. Its large homologous α and β subunits regulate the activity of the catalytic γ subunit and account for 81% of PhK’s mass. Both subunits are thought to be multidomai...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 2010-08, Vol.49 (31), p.6505-6507
Hauptverfasser:	Nadeau, Owen W, Liu, Weiya, Boulatnikov, Igor G, Sage, Jessica M, Peters, Jennifer L, Carlson, Gerald M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acarbose - pharmacology Enzyme Activation - drug effects Enzyme Inhibitors Glucan 1,4-alpha-Glucosidase - antagonists & inhibitors Humans Hypoglycemic Agents Phosphorylase Kinase - chemistry Phosphorylase Kinase - drug effects Protein Binding Protein Conformation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!