Persistence of Sleep-Associated Decrease in GnRH Pulse Frequency in the Absence of Gonadal Steroids
Context: There is dramatic slowing of GnRH pulse frequency during sleep in the early follicular phase of the menstrual cycle, but it is unknown whether this represents a primary effect of sleep or is dependent upon the sex steroid environment. Objectives: Our objective was to determine 1) whether sl...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2011-08, Vol.96 (8), p.2590-2595 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Shaw, Natalie D Gill, Sabrina Lavoie, Helene B Marsh, Erica E Hall, Janet E |
| description | Context:
There is dramatic slowing of GnRH pulse frequency during sleep in the early follicular phase of the menstrual cycle, but it is unknown whether this represents a primary effect of sleep or is dependent upon the sex steroid environment.
Objectives:
Our objective was to determine 1) whether sleep affects GnRH pulse frequency in postmenopausal women (PMW) in whom gonadal hormones are low and 2) whether this relationship changes with aging.
Design and Setting:
Studies were performed in the Clinical Research Center of an academic medical center.
Subjects:
Subjects included healthy PMW, 45–55 (n = 8) and 70–80 (n = 6) years old.
Interventions:
Subjects were studied during one night of polysomnographic-recorded sleep and one night of monitored wake during which blood was sampled every 5 min for 8 h.
Main Outcome Measures:
Pulsatile secretion of free α-subunit (FAS), a marker of GnRH secretion, was assessed.
Results:
There were no differences in sleep macroarchitecture or sleep efficiency [75 ± 12% (mean ± sd)] between older and younger PMW. The FAS interpulse interval was longer during sleep than nighttime wake in all women (60.5 ± 4.3 vs. 52.0 ± 2.8 min, P = 0.03) with a similar effect in the two groups. FAS pulse amplitude did not differ between sleep and wake periods (474.8 ± 36.7 vs. 478.2 ± 36.5 ng/liter, P = 0.9).
Conclusions:
Sleep is associated with a significant decline in GnRH pulse frequency in both older and younger PMW. Its persistence in PMW reinforces the important connection between sleep and GnRH secretion. |
| doi_str_mv | 10.1210/jc.2011-1188 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3146798</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>881472361</sourcerecordid><originalsourceid>FETCH-LOGICAL-c457t-ffe02f5e3aea2747f697702ce6caa24fb9c4c6846bc6e2c21161e325a654994f3</originalsourceid><addsrcrecordid>eNptkdFrFDEQxoMo9qy--Sz7Ir64NZPNJrsvwlHtVShYrIJvITc7sTn2kjPZFfrfm-OuVcGnMMlvvm8yH2MvgZ-BAP5ug2eCA9QAXfeILaCXba2h14_ZgnMBda_F9xP2LOcN5yBl2zxlJwKUVI3qFwyvKWWfJwpIVXTVzUi0q5c5R_R2oqH6QJjIZqp8qFbhy2V1PY-lukj0cy5Nd_v76Zaq5Trfa6xisIMdq5uJUvRDfs6eOFuaXhzPU_bt4uPX88v66vPq0_nyqkbZ6ql2jrhwLTWWrNBSO9VrzQWSQmuFdOseJapOqjUqEigAFFAjWqta2ffSNafs_UF3N6-3NCCFKdnR7JLf2nRnovXm35fgb82P-Ms0IJXuuyLw5iiQYvldnszWZ6RxtIHinE3XgdSiUVDItwcSU8w5kXtwAW72sZgNmn0sZh9LwV_9PdkDfJ9DAV4fAZvRji7ZgD7_4aQUreaycM2BozBETD7QLlHOZhPnFMpu_2__GwGTp28</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>881472361</pqid></control><display><type>article</type><title>Persistence of Sleep-Associated Decrease in GnRH Pulse Frequency in the Absence of Gonadal Steroids</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Shaw, Natalie D ; Gill, Sabrina ; Lavoie, Helene B ; Marsh, Erica E ; Hall, Janet E</creator><creatorcontrib>Shaw, Natalie D ; Gill, Sabrina ; Lavoie, Helene B ; Marsh, Erica E ; Hall, Janet E</creatorcontrib><description>Context:
There is dramatic slowing of GnRH pulse frequency during sleep in the early follicular phase of the menstrual cycle, but it is unknown whether this represents a primary effect of sleep or is dependent upon the sex steroid environment.
Objectives:
Our objective was to determine 1) whether sleep affects GnRH pulse frequency in postmenopausal women (PMW) in whom gonadal hormones are low and 2) whether this relationship changes with aging.
Design and Setting:
Studies were performed in the Clinical Research Center of an academic medical center.
Subjects:
Subjects included healthy PMW, 45–55 (n = 8) and 70–80 (n = 6) years old.
Interventions:
Subjects were studied during one night of polysomnographic-recorded sleep and one night of monitored wake during which blood was sampled every 5 min for 8 h.
Main Outcome Measures:
Pulsatile secretion of free α-subunit (FAS), a marker of GnRH secretion, was assessed.
Results:
There were no differences in sleep macroarchitecture or sleep efficiency [75 ± 12% (mean ± sd)] between older and younger PMW. The FAS interpulse interval was longer during sleep than nighttime wake in all women (60.5 ± 4.3 vs. 52.0 ± 2.8 min, P = 0.03) with a similar effect in the two groups. FAS pulse amplitude did not differ between sleep and wake periods (474.8 ± 36.7 vs. 478.2 ± 36.5 ng/liter, P = 0.9).
Conclusions:
Sleep is associated with a significant decline in GnRH pulse frequency in both older and younger PMW. Its persistence in PMW reinforces the important connection between sleep and GnRH secretion.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2011-1188</identifier><identifier>PMID: 21646369</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Aged ; Aged, 80 and over ; Aging - physiology ; Biological and medical sciences ; Circadian Rhythm - physiology ; Endocrine Research ; Endocrinopathies ; Estradiol - blood ; Estradiol - deficiency ; Feeding. Feeding behavior ; Female ; Follicle Stimulating Hormone - blood ; Follicular Phase - physiology ; Fundamental and applied biological sciences. Psychology ; Gonadal Steroid Hormones - blood ; Gonadotropin-Releasing Hormone - blood ; Gonadotropin-Releasing Hormone - metabolism ; Humans ; Luteinizing Hormone - blood ; Medical sciences ; Middle Aged ; Postmenopause - physiology ; Progesterone - blood ; Progesterone - deficiency ; Sleep - physiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2011-08, Vol.96 (8), p.2590-2595</ispartof><rights>Copyright © 2011 by The Endocrine Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 by The Endocrine Society 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-ffe02f5e3aea2747f697702ce6caa24fb9c4c6846bc6e2c21161e325a654994f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24425704$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21646369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shaw, Natalie D</creatorcontrib><creatorcontrib>Gill, Sabrina</creatorcontrib><creatorcontrib>Lavoie, Helene B</creatorcontrib><creatorcontrib>Marsh, Erica E</creatorcontrib><creatorcontrib>Hall, Janet E</creatorcontrib><title>Persistence of Sleep-Associated Decrease in GnRH Pulse Frequency in the Absence of Gonadal Steroids</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
There is dramatic slowing of GnRH pulse frequency during sleep in the early follicular phase of the menstrual cycle, but it is unknown whether this represents a primary effect of sleep or is dependent upon the sex steroid environment.
Objectives:
Our objective was to determine 1) whether sleep affects GnRH pulse frequency in postmenopausal women (PMW) in whom gonadal hormones are low and 2) whether this relationship changes with aging.
Design and Setting:
Studies were performed in the Clinical Research Center of an academic medical center.
Subjects:
Subjects included healthy PMW, 45–55 (n = 8) and 70–80 (n = 6) years old.
Interventions:
Subjects were studied during one night of polysomnographic-recorded sleep and one night of monitored wake during which blood was sampled every 5 min for 8 h.
Main Outcome Measures:
Pulsatile secretion of free α-subunit (FAS), a marker of GnRH secretion, was assessed.
Results:
There were no differences in sleep macroarchitecture or sleep efficiency [75 ± 12% (mean ± sd)] between older and younger PMW. The FAS interpulse interval was longer during sleep than nighttime wake in all women (60.5 ± 4.3 vs. 52.0 ± 2.8 min, P = 0.03) with a similar effect in the two groups. FAS pulse amplitude did not differ between sleep and wake periods (474.8 ± 36.7 vs. 478.2 ± 36.5 ng/liter, P = 0.9).
Conclusions:
Sleep is associated with a significant decline in GnRH pulse frequency in both older and younger PMW. Its persistence in PMW reinforces the important connection between sleep and GnRH secretion.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm - physiology</subject><subject>Endocrine Research</subject><subject>Endocrinopathies</subject><subject>Estradiol - blood</subject><subject>Estradiol - deficiency</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicular Phase - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>Gonadotropin-Releasing Hormone - blood</subject><subject>Gonadotropin-Releasing Hormone - metabolism</subject><subject>Humans</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postmenopause - physiology</subject><subject>Progesterone - blood</subject><subject>Progesterone - deficiency</subject><subject>Sleep - physiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkdFrFDEQxoMo9qy--Sz7Ir64NZPNJrsvwlHtVShYrIJvITc7sTn2kjPZFfrfm-OuVcGnMMlvvm8yH2MvgZ-BAP5ug2eCA9QAXfeILaCXba2h14_ZgnMBda_F9xP2LOcN5yBl2zxlJwKUVI3qFwyvKWWfJwpIVXTVzUi0q5c5R_R2oqH6QJjIZqp8qFbhy2V1PY-lukj0cy5Nd_v76Zaq5Trfa6xisIMdq5uJUvRDfs6eOFuaXhzPU_bt4uPX88v66vPq0_nyqkbZ6ql2jrhwLTWWrNBSO9VrzQWSQmuFdOseJapOqjUqEigAFFAjWqta2ffSNafs_UF3N6-3NCCFKdnR7JLf2nRnovXm35fgb82P-Ms0IJXuuyLw5iiQYvldnszWZ6RxtIHinE3XgdSiUVDItwcSU8w5kXtwAW72sZgNmn0sZh9LwV_9PdkDfJ9DAV4fAZvRji7ZgD7_4aQUreaycM2BozBETD7QLlHOZhPnFMpu_2__GwGTp28</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Shaw, Natalie D</creator><creator>Gill, Sabrina</creator><creator>Lavoie, Helene B</creator><creator>Marsh, Erica E</creator><creator>Hall, Janet E</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110801</creationdate><title>Persistence of Sleep-Associated Decrease in GnRH Pulse Frequency in the Absence of Gonadal Steroids</title><author>Shaw, Natalie D ; Gill, Sabrina ; Lavoie, Helene B ; Marsh, Erica E ; Hall, Janet E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-ffe02f5e3aea2747f697702ce6caa24fb9c4c6846bc6e2c21161e325a654994f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm - physiology</topic><topic>Endocrine Research</topic><topic>Endocrinopathies</topic><topic>Estradiol - blood</topic><topic>Estradiol - deficiency</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicular Phase - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>Gonadotropin-Releasing Hormone - blood</topic><topic>Gonadotropin-Releasing Hormone - metabolism</topic><topic>Humans</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postmenopause - physiology</topic><topic>Progesterone - blood</topic><topic>Progesterone - deficiency</topic><topic>Sleep - physiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shaw, Natalie D</creatorcontrib><creatorcontrib>Gill, Sabrina</creatorcontrib><creatorcontrib>Lavoie, Helene B</creatorcontrib><creatorcontrib>Marsh, Erica E</creatorcontrib><creatorcontrib>Hall, Janet E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shaw, Natalie D</au><au>Gill, Sabrina</au><au>Lavoie, Helene B</au><au>Marsh, Erica E</au><au>Hall, Janet E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistence of Sleep-Associated Decrease in GnRH Pulse Frequency in the Absence of Gonadal Steroids</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>96</volume><issue>8</issue><spage>2590</spage><epage>2595</epage><pages>2590-2595</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context:
There is dramatic slowing of GnRH pulse frequency during sleep in the early follicular phase of the menstrual cycle, but it is unknown whether this represents a primary effect of sleep or is dependent upon the sex steroid environment.
Objectives:
Our objective was to determine 1) whether sleep affects GnRH pulse frequency in postmenopausal women (PMW) in whom gonadal hormones are low and 2) whether this relationship changes with aging.
Design and Setting:
Studies were performed in the Clinical Research Center of an academic medical center.
Subjects:
Subjects included healthy PMW, 45–55 (n = 8) and 70–80 (n = 6) years old.
Interventions:
Subjects were studied during one night of polysomnographic-recorded sleep and one night of monitored wake during which blood was sampled every 5 min for 8 h.
Main Outcome Measures:
Pulsatile secretion of free α-subunit (FAS), a marker of GnRH secretion, was assessed.
Results:
There were no differences in sleep macroarchitecture or sleep efficiency [75 ± 12% (mean ± sd)] between older and younger PMW. The FAS interpulse interval was longer during sleep than nighttime wake in all women (60.5 ± 4.3 vs. 52.0 ± 2.8 min, P = 0.03) with a similar effect in the two groups. FAS pulse amplitude did not differ between sleep and wake periods (474.8 ± 36.7 vs. 478.2 ± 36.5 ng/liter, P = 0.9).
Conclusions:
Sleep is associated with a significant decline in GnRH pulse frequency in both older and younger PMW. Its persistence in PMW reinforces the important connection between sleep and GnRH secretion.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>21646369</pmid><doi>10.1210/jc.2011-1188</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2011-08, Vol.96 (8), p.2590-2595 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3146798 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Aging - physiology Biological and medical sciences Circadian Rhythm - physiology Endocrine Research Endocrinopathies Estradiol - blood Estradiol - deficiency Feeding. Feeding behavior Female Follicle Stimulating Hormone - blood Follicular Phase - physiology Fundamental and applied biological sciences. Psychology Gonadal Steroid Hormones - blood Gonadotropin-Releasing Hormone - blood Gonadotropin-Releasing Hormone - metabolism Humans Luteinizing Hormone - blood Medical sciences Middle Aged Postmenopause - physiology Progesterone - blood Progesterone - deficiency Sleep - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Persistence of Sleep-Associated Decrease in GnRH Pulse Frequency in the Absence of Gonadal Steroids |
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