Asporin expression is highly regulated in human chondrocytes

A significant association between a polymorphism in the D repeat of the gene encoding asporin and osteoarthritis, the most frequent of articular diseases, has been recently reported. The goal of the present study was to investigate the expression of this new class I small leucine-rich proteoglycan (...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Mass.), 2011-07, Vol.17 (7-8), p.816-823
Hauptverfasser:	Duval, Elise, Bigot, Nicolas, Hervieu, Magalie, Kou, Ikuyo, Leclercq, Sylvain, Galéra, Philippe, Boumediene, Karim, Baugé, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Binding Sites - genetics Biochemistry, Molecular Biology Blotting, Western Cartilage Cartilage, Articular - cytology Cell Dedifferentiation - genetics Cell Differentiation - genetics Cells, Cultured Cellular Biology Chondrocytes Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism Cytokines Down-Regulation - drug effects Electrophoretic Mobility Shift Assay Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Gene Expression - drug effects Gene Expression - genetics Human health and pathology Humans Interleukin-1beta Interleukin-1beta - pharmacology Life Sciences Middle Aged Osteoarthritis Polymerase Chain Reaction Primary Cell Culture Promoter Regions, Genetic - genetics Protein Binding Proteoglycans Reverse Transcriptase Polymerase Chain Reaction Reverse Transcription Rhumatology and musculoskeletal system RNA, Messenger Sp1 Transcription Factor Sp1 Transcription Factor - genetics Sp1 Transcription Factor - metabolism Transfection Transforming Growth Factor beta1 Transforming Growth Factor beta1 - pharmacology Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha - pharmacology
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