Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline

Our aim was to test the association of vascular risk factor exposure in midlife with progression of MRI markers of brain aging and measures of cognitive decline. A total of 1,352 participants without dementia from the prospective Framingham Offspring Cohort Study were examined. Multivariable linear...

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Veröffentlicht in:	Neurology 2011-08, Vol.77 (5), p.461-468
Hauptverfasser:	DEBETTE, S, SESHADRI, S, BEISER, A, AU, R, HIMALI, J. J, PALUMBO, C, WOLF, P. A, DECARLI, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging Apolipoproteins E - genetics Biological and medical sciences Brain - pathology Cerebrovascular Circulation - physiology Cognition Disorders - pathology Cohort Studies Female Humans Hypertension - physiopathology Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Neurology Neuropsychological Tests Regression Analysis Risk Factors Statistics as Topic Vascular diseases and vascular malformations of the nervous system
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