Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis

Prostacyclin is increasingly implicated in re-endothelialization and angiogenesis but through largely unknown mechanisms. Herein the high-density lipoprotein (HDL) scavenger receptor class B, type 1 (SR-B1) adapter protein PDZ domain-containing protein 1 (PDZK1) was identified as an interactant of t...

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Veröffentlicht in:	Molecular biology of the cell 2011-08, Vol.22 (15), p.2664-2679
Hauptverfasser:	Turner, Elizebeth C, Mulvaney, Eamon P, Reid, Helen M, Kinsella, B Therese
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Benzyl Compounds - pharmacology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Membrane - metabolism Cell Movement - drug effects Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Epoprostenol - analogs & derivatives Epoprostenol - pharmacology Gene Expression Regulation HEK293 Cells Humans Imidazoles - pharmacology Lipoproteins, HDL - metabolism Mice Mice, Knockout Neovascularization, Physiologic - drug effects PDZ Domains Phosphorylation Protein Binding - drug effects Protein Structure, Tertiary Receptors, Epoprostenol Receptors, Prostaglandin - antagonists & inhibitors Receptors, Prostaglandin - genetics Receptors, Prostaglandin - metabolism Signal Transduction
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