Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts

Thy-1 is a cell surface glycoprotein present on normal lung fibroblasts but absent from the fibroblastic foci of idiopathic pulmonary fibrosis. Thy-1 correlates inversely with fibrogenic phenotypic characteristics and functions as a "fibrosis suppressor." Promoter region hypermethylation c...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2011-07, Vol.45 (1), p.16-23
Hauptverfasser:	Sanders, Yan Y, Tollefsbol, Trygve O, Varisco, Brian M, Hagood, James S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured CpG Islands - genetics DNA Methylation - drug effects DNA Methylation - genetics Dose-Response Relationship, Drug Epigenesis, Genetic Fibroblasts - metabolism Fibroblasts - pathology Gene Silencing Histone Deacetylase Inhibitors - pharmacology Histones - genetics Histones - metabolism Hydroxamic Acids - pharmacology Lung - metabolism Lung - pathology Methylation - drug effects Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - genetics Protein Processing, Post-Translational - drug effects Protein Processing, Post-Translational - genetics Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Rats Thy-1 Antigens - biosynthesis Thy-1 Antigens - genetics Time Factors Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics
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