Tissue elasticity properties as biomarkers for prostate cancer
In this paper we evaluate tissue elasticity as a longstanding but qualitative biomarker for prostate cancer and sonoelastography as an emerging imaging tool for providing qualitative and quantitative measurements of prostate tissue stiffness. A Kelvin-Voigt Fractional Derivative (KVFD) viscoelastic...
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| Veröffentlicht in: | Cancer biomarkers : section A of Disease markers 2008-01, Vol.4 (4-5), p.213-225 |
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| container_title | Cancer biomarkers : section A of Disease markers |
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| creator | Hoyt, Kenneth Castaneda, Benjamin Zhang, Man Nigwekar, Priya di Sant'agnese, P Anthony Joseph, Jean V Strang, John Rubens, Deborah J Parker, Kevin J |
| description | In this paper we evaluate tissue elasticity as a longstanding but qualitative biomarker for prostate cancer and sonoelastography as an emerging imaging tool for providing qualitative and quantitative measurements of prostate tissue stiffness. A Kelvin-Voigt Fractional Derivative (KVFD) viscoelastic model was used to characterize mechanical stress relaxation data measured from human prostate tissue samples. Mechanical testing results revealed that the viscosity parameter for cancerous prostate tissue is greater than that derived from normal tissue by a factor of approximately 2.4. It was also determined that a significant difference exists between normal and cancerous prostate tissue stiffness (p < 0.01) yielding an average elastic contrast that increases from 2.1 at 0.1 Hz to 2.5 at 150 Hz. Qualitative sonoelastographic results show promise for cancer detection in prostate and may prove to be an effective adjunct imaging technique for biopsy guidance. Elasticity images obtained with quantitative sonoelastography agree with mechanical testing and histological results. Overall, results indicate tissue elasticity is a promising biomarker for prostate cancer. |
| doi_str_mv | 10.3233/cbm-2008-44-505 |
| format | Article |
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A Kelvin-Voigt Fractional Derivative (KVFD) viscoelastic model was used to characterize mechanical stress relaxation data measured from human prostate tissue samples. Mechanical testing results revealed that the viscosity parameter for cancerous prostate tissue is greater than that derived from normal tissue by a factor of approximately 2.4. It was also determined that a significant difference exists between normal and cancerous prostate tissue stiffness (p < 0.01) yielding an average elastic contrast that increases from 2.1 at 0.1 Hz to 2.5 at 150 Hz. Qualitative sonoelastographic results show promise for cancer detection in prostate and may prove to be an effective adjunct imaging technique for biopsy guidance. Elasticity images obtained with quantitative sonoelastography agree with mechanical testing and histological results. 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Overall, results indicate tissue elasticity is a promising biomarker for prostate cancer.</description><subject>Biomarkers - analysis</subject><subject>Diagnosis, Differential</subject><subject>Elastic Modulus</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Humans</subject><subject>Male</subject><subject>Prostate - diagnostic imaging</subject><subject>Prostatic Neoplasms - diagnostic imaging</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><subject>Viscosity</subject><issn>1574-0153</issn><issn>1875-8592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVULlOAzEUtBCIhEBNh7aiW-JzjyYSRFxSEE2oLa_3GQx7YXuR8vc4SsRRvSfNvJl5g9A5wVeMMjbXVZtSjIuU81RgcYCmpMhFWoiSHsZd5DzFRLAJOvH-HWPOCC2P0YQUpchzQqdosbbej5BAo3yw2oZNMrh-ABcs-ET5pLJ9q9wHOJ-Y3m1BH1SARKtOgztFR0Y1Hs72c4Ze7m7Xy4d09Xz_uLxepVpgFtK8AAZcZBXFhPKcG02hrIETyDCojGKmqyKrtcE1qUzOgJAyMxkQRuvMKMxmaLHTHcaqhVpDF5xq5OBsDLeRvbLyP9LZN_naf0lGOOeliAKXewHXf47gg2yt19A0qoN-9DIr82jJeSTOd0QdP_UOzI8JwXLbuVzePMlt55JzGTuPFxd_s_3y9yWzb2iUftg</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Hoyt, Kenneth</creator><creator>Castaneda, Benjamin</creator><creator>Zhang, Man</creator><creator>Nigwekar, Priya</creator><creator>di Sant'agnese, P Anthony</creator><creator>Joseph, Jean V</creator><creator>Strang, John</creator><creator>Rubens, Deborah J</creator><creator>Parker, Kevin J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080101</creationdate><title>Tissue elasticity properties as biomarkers for prostate cancer</title><author>Hoyt, Kenneth ; Castaneda, Benjamin ; Zhang, Man ; Nigwekar, Priya ; di Sant'agnese, P Anthony ; Joseph, Jean V ; Strang, John ; Rubens, Deborah J ; Parker, Kevin J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-78e3e456b2012474fc2e9de41e60ea6203cb86dcf0d1bf73e1196f6e132d6fa03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biomarkers - analysis</topic><topic>Diagnosis, Differential</topic><topic>Elastic Modulus</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Humans</topic><topic>Male</topic><topic>Prostate - diagnostic imaging</topic><topic>Prostatic Neoplasms - diagnostic imaging</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoyt, Kenneth</creatorcontrib><creatorcontrib>Castaneda, Benjamin</creatorcontrib><creatorcontrib>Zhang, Man</creatorcontrib><creatorcontrib>Nigwekar, Priya</creatorcontrib><creatorcontrib>di Sant'agnese, P Anthony</creatorcontrib><creatorcontrib>Joseph, Jean V</creatorcontrib><creatorcontrib>Strang, John</creatorcontrib><creatorcontrib>Rubens, Deborah J</creatorcontrib><creatorcontrib>Parker, Kevin J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer biomarkers : section A of Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoyt, Kenneth</au><au>Castaneda, Benjamin</au><au>Zhang, Man</au><au>Nigwekar, Priya</au><au>di Sant'agnese, P Anthony</au><au>Joseph, Jean V</au><au>Strang, John</au><au>Rubens, Deborah J</au><au>Parker, Kevin J</au><au>Feleppa, Ernest J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue elasticity properties as biomarkers for prostate cancer</atitle><jtitle>Cancer biomarkers : section A of Disease markers</jtitle><addtitle>Cancer Biomark</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>4</volume><issue>4-5</issue><spage>213</spage><epage>225</epage><pages>213-225</pages><issn>1574-0153</issn><eissn>1875-8592</eissn><abstract>In this paper we evaluate tissue elasticity as a longstanding but qualitative biomarker for prostate cancer and sonoelastography as an emerging imaging tool for providing qualitative and quantitative measurements of prostate tissue stiffness. A Kelvin-Voigt Fractional Derivative (KVFD) viscoelastic model was used to characterize mechanical stress relaxation data measured from human prostate tissue samples. Mechanical testing results revealed that the viscosity parameter for cancerous prostate tissue is greater than that derived from normal tissue by a factor of approximately 2.4. It was also determined that a significant difference exists between normal and cancerous prostate tissue stiffness (p < 0.01) yielding an average elastic contrast that increases from 2.1 at 0.1 Hz to 2.5 at 150 Hz. Qualitative sonoelastographic results show promise for cancer detection in prostate and may prove to be an effective adjunct imaging technique for biopsy guidance. Elasticity images obtained with quantitative sonoelastography agree with mechanical testing and histological results. Overall, results indicate tissue elasticity is a promising biomarker for prostate cancer.</abstract><cop>Netherlands</cop><pmid>18957712</pmid><doi>10.3233/cbm-2008-44-505</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer biomarkers : section A of Disease markers, 2008-01, Vol.4 (4-5), p.213-225 |
| issn | 1574-0153 1875-8592 |
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| source | MEDLINE; Sage Journals GOLD Open Access 2024 |
| subjects | Biomarkers - analysis Diagnosis, Differential Elastic Modulus Elasticity Imaging Techniques - methods Humans Male Prostate - diagnostic imaging Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - pathology Reference Values Reproducibility of Results Viscosity |
| title | Tissue elasticity properties as biomarkers for prostate cancer |
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