Miniaturized probe for femtosecond laser microsurgery and two-photon imaging
Combined two-photon fluorescence microscopy and femtosecond laser microsurgery has many potential biomedical applications as a powerful "seek-and-treat" tool. Towards developing such a tool, we demonstrate a miniaturized probe which combines these techniques in a compact housing. The devic...
Gespeichert in:
| Veröffentlicht in: | Optics express 2008-06, Vol.16 (13), p.9996-10005 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 10005 |
|---|---|
| container_issue | 13 |
| container_start_page | 9996 |
| container_title | Optics express |
| container_volume | 16 |
| creator | Hoy, Christopher L Durr, Nicholas J Chen, Pengyuan Piyawattanametha, Wibool Ra, Hyejun Solgaard, Olav Ben-Yakar, Adela |
| description | Combined two-photon fluorescence microscopy and femtosecond laser microsurgery has many potential biomedical applications as a powerful "seek-and-treat" tool. Towards developing such a tool, we demonstrate a miniaturized probe which combines these techniques in a compact housing. The device is 10 x 15 x 40 mm(3) in size and uses an aircore photonic crystal fiber to deliver femtosecond laser pulses at 80 MHz repetition rate for imaging and 1 kHz for microsurgery. A fast two-axis microelectromechanical system scanning mirror is driven at resonance to produce Lissajous beam scanning at 10 frames per second. Field of view is 310 microm in diameter and the lateral and axial resolutions are 1.64 microm and 16.4 microm, respectively. Combined imaging and microsurgery is demonstrated using live cancer cells. |
| doi_str_mv | 10.1364/oe.16.009996 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3143712</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69248693</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-9fea4241fefdc6ecbd6fe2a0b0ea93f689b9791d6b8f08011ffebff9b2cb9c373</originalsourceid><addsrcrecordid>eNpVkL1PwzAQxS0EoqWwMaNMTKTYievECxKqyodU1AVmy3bOqVESBzsBlb-eVK2gTHe6--ndu4fQJcFTkjJ662BK2BRjzjk7QmOCOY0pzrPjg36EzkJ4x5jQjGenaETyWTabZXiMli-2sbLrvf2GImq9UxAZ5yMDdecCaNcUUSUD-Ki22rvQ-xL8JpLDuPtycbt2nWsiW8vSNuU5OjGyCnCxrxP09rB4nT_Fy9Xj8_x-GWtK8y7mBiRNKDFgCs1Aq4IZSCRWGCRPDcu54hknBVO5wTkmxBhQxnCVaMV1mqUTdLfTbXtVQ6Gh6bysROsHH34jnLTi_6axa1G6T5ESmmYkGQSu9wLeffQQOlHboKGqZAOuD4LxhOaMpwN4swO3vwcP5vcIwWIbv1gtBGFiF_-AXx0a-4P3eac_jGiEZQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69248693</pqid></control><display><type>article</type><title>Miniaturized probe for femtosecond laser microsurgery and two-photon imaging</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Hoy, Christopher L ; Durr, Nicholas J ; Chen, Pengyuan ; Piyawattanametha, Wibool ; Ra, Hyejun ; Solgaard, Olav ; Ben-Yakar, Adela</creator><creatorcontrib>Hoy, Christopher L ; Durr, Nicholas J ; Chen, Pengyuan ; Piyawattanametha, Wibool ; Ra, Hyejun ; Solgaard, Olav ; Ben-Yakar, Adela</creatorcontrib><description>Combined two-photon fluorescence microscopy and femtosecond laser microsurgery has many potential biomedical applications as a powerful "seek-and-treat" tool. Towards developing such a tool, we demonstrate a miniaturized probe which combines these techniques in a compact housing. The device is 10 x 15 x 40 mm(3) in size and uses an aircore photonic crystal fiber to deliver femtosecond laser pulses at 80 MHz repetition rate for imaging and 1 kHz for microsurgery. A fast two-axis microelectromechanical system scanning mirror is driven at resonance to produce Lissajous beam scanning at 10 frames per second. Field of view is 310 microm in diameter and the lateral and axial resolutions are 1.64 microm and 16.4 microm, respectively. Combined imaging and microsurgery is demonstrated using live cancer cells.</description><identifier>ISSN: 1094-4087</identifier><identifier>EISSN: 1094-4087</identifier><identifier>DOI: 10.1364/oe.16.009996</identifier><identifier>PMID: 18575570</identifier><language>eng</language><publisher>United States</publisher><subject>Endoscopes ; Equipment Design ; Equipment Failure Analysis ; Laser Therapy - instrumentation ; Microscopy, Fluorescence, Multiphoton - instrumentation ; Microsurgery - instrumentation ; Miniaturization ; Surgery, Computer-Assisted - instrumentation ; Transducers</subject><ispartof>Optics express, 2008-06, Vol.16 (13), p.9996-10005</ispartof><rights>2008 Optical Society of America 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-9fea4241fefdc6ecbd6fe2a0b0ea93f689b9791d6b8f08011ffebff9b2cb9c373</citedby><cites>FETCH-LOGICAL-c448t-9fea4241fefdc6ecbd6fe2a0b0ea93f689b9791d6b8f08011ffebff9b2cb9c373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18575570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoy, Christopher L</creatorcontrib><creatorcontrib>Durr, Nicholas J</creatorcontrib><creatorcontrib>Chen, Pengyuan</creatorcontrib><creatorcontrib>Piyawattanametha, Wibool</creatorcontrib><creatorcontrib>Ra, Hyejun</creatorcontrib><creatorcontrib>Solgaard, Olav</creatorcontrib><creatorcontrib>Ben-Yakar, Adela</creatorcontrib><title>Miniaturized probe for femtosecond laser microsurgery and two-photon imaging</title><title>Optics express</title><addtitle>Opt Express</addtitle><description>Combined two-photon fluorescence microscopy and femtosecond laser microsurgery has many potential biomedical applications as a powerful "seek-and-treat" tool. Towards developing such a tool, we demonstrate a miniaturized probe which combines these techniques in a compact housing. The device is 10 x 15 x 40 mm(3) in size and uses an aircore photonic crystal fiber to deliver femtosecond laser pulses at 80 MHz repetition rate for imaging and 1 kHz for microsurgery. A fast two-axis microelectromechanical system scanning mirror is driven at resonance to produce Lissajous beam scanning at 10 frames per second. Field of view is 310 microm in diameter and the lateral and axial resolutions are 1.64 microm and 16.4 microm, respectively. Combined imaging and microsurgery is demonstrated using live cancer cells.</description><subject>Endoscopes</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Laser Therapy - instrumentation</subject><subject>Microscopy, Fluorescence, Multiphoton - instrumentation</subject><subject>Microsurgery - instrumentation</subject><subject>Miniaturization</subject><subject>Surgery, Computer-Assisted - instrumentation</subject><subject>Transducers</subject><issn>1094-4087</issn><issn>1094-4087</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkL1PwzAQxS0EoqWwMaNMTKTYievECxKqyodU1AVmy3bOqVESBzsBlb-eVK2gTHe6--ndu4fQJcFTkjJ662BK2BRjzjk7QmOCOY0pzrPjg36EzkJ4x5jQjGenaETyWTabZXiMli-2sbLrvf2GImq9UxAZ5yMDdecCaNcUUSUD-Ki22rvQ-xL8JpLDuPtycbt2nWsiW8vSNuU5OjGyCnCxrxP09rB4nT_Fy9Xj8_x-GWtK8y7mBiRNKDFgCs1Aq4IZSCRWGCRPDcu54hknBVO5wTkmxBhQxnCVaMV1mqUTdLfTbXtVQ6Gh6bysROsHH34jnLTi_6axa1G6T5ESmmYkGQSu9wLeffQQOlHboKGqZAOuD4LxhOaMpwN4swO3vwcP5vcIwWIbv1gtBGFiF_-AXx0a-4P3eac_jGiEZQ</recordid><startdate>20080623</startdate><enddate>20080623</enddate><creator>Hoy, Christopher L</creator><creator>Durr, Nicholas J</creator><creator>Chen, Pengyuan</creator><creator>Piyawattanametha, Wibool</creator><creator>Ra, Hyejun</creator><creator>Solgaard, Olav</creator><creator>Ben-Yakar, Adela</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080623</creationdate><title>Miniaturized probe for femtosecond laser microsurgery and two-photon imaging</title><author>Hoy, Christopher L ; Durr, Nicholas J ; Chen, Pengyuan ; Piyawattanametha, Wibool ; Ra, Hyejun ; Solgaard, Olav ; Ben-Yakar, Adela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-9fea4241fefdc6ecbd6fe2a0b0ea93f689b9791d6b8f08011ffebff9b2cb9c373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Endoscopes</topic><topic>Equipment Design</topic><topic>Equipment Failure Analysis</topic><topic>Laser Therapy - instrumentation</topic><topic>Microscopy, Fluorescence, Multiphoton - instrumentation</topic><topic>Microsurgery - instrumentation</topic><topic>Miniaturization</topic><topic>Surgery, Computer-Assisted - instrumentation</topic><topic>Transducers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoy, Christopher L</creatorcontrib><creatorcontrib>Durr, Nicholas J</creatorcontrib><creatorcontrib>Chen, Pengyuan</creatorcontrib><creatorcontrib>Piyawattanametha, Wibool</creatorcontrib><creatorcontrib>Ra, Hyejun</creatorcontrib><creatorcontrib>Solgaard, Olav</creatorcontrib><creatorcontrib>Ben-Yakar, Adela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Optics express</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoy, Christopher L</au><au>Durr, Nicholas J</au><au>Chen, Pengyuan</au><au>Piyawattanametha, Wibool</au><au>Ra, Hyejun</au><au>Solgaard, Olav</au><au>Ben-Yakar, Adela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Miniaturized probe for femtosecond laser microsurgery and two-photon imaging</atitle><jtitle>Optics express</jtitle><addtitle>Opt Express</addtitle><date>2008-06-23</date><risdate>2008</risdate><volume>16</volume><issue>13</issue><spage>9996</spage><epage>10005</epage><pages>9996-10005</pages><issn>1094-4087</issn><eissn>1094-4087</eissn><abstract>Combined two-photon fluorescence microscopy and femtosecond laser microsurgery has many potential biomedical applications as a powerful "seek-and-treat" tool. Towards developing such a tool, we demonstrate a miniaturized probe which combines these techniques in a compact housing. The device is 10 x 15 x 40 mm(3) in size and uses an aircore photonic crystal fiber to deliver femtosecond laser pulses at 80 MHz repetition rate for imaging and 1 kHz for microsurgery. A fast two-axis microelectromechanical system scanning mirror is driven at resonance to produce Lissajous beam scanning at 10 frames per second. Field of view is 310 microm in diameter and the lateral and axial resolutions are 1.64 microm and 16.4 microm, respectively. Combined imaging and microsurgery is demonstrated using live cancer cells.</abstract><cop>United States</cop><pmid>18575570</pmid><doi>10.1364/oe.16.009996</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1094-4087 |
| ispartof | Optics express, 2008-06, Vol.16 (13), p.9996-10005 |
| issn | 1094-4087 1094-4087 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3143712 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Endoscopes Equipment Design Equipment Failure Analysis Laser Therapy - instrumentation Microscopy, Fluorescence, Multiphoton - instrumentation Microsurgery - instrumentation Miniaturization Surgery, Computer-Assisted - instrumentation Transducers |
| title | Miniaturized probe for femtosecond laser microsurgery and two-photon imaging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T17%3A50%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Miniaturized%20probe%20for%20femtosecond%20laser%20microsurgery%20and%20two-photon%20imaging&rft.jtitle=Optics%20express&rft.au=Hoy,%20Christopher%20L&rft.date=2008-06-23&rft.volume=16&rft.issue=13&rft.spage=9996&rft.epage=10005&rft.pages=9996-10005&rft.issn=1094-4087&rft.eissn=1094-4087&rft_id=info:doi/10.1364/oe.16.009996&rft_dat=%3Cproquest_pubme%3E69248693%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69248693&rft_id=info:pmid/18575570&rfr_iscdi=true |