Neuroprotection mediated by changes in the endothelial actin cytoskeleton

Cerebral blood flow is regulated by endothelium-derived nitric oxide (NO), and endothelial NO synthase-deficient (eNOS-deficient; eNOS(-/-)) mice develop larger cerebral infarctions following middle cerebral artery (MCA) occlusion. We report that disruption of Rho-mediated endothelial actin cytoskel...

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Veröffentlicht in:	The Journal of clinical investigation 2000-07, Vol.106 (1), p.15-24
Hauptverfasser:	Laufs, U, Endres, M, Stagliano, N, Amin-Hanjani, S, Chui, D S, Yang, S X, Simoncini, T, Yamada, M, Rabkin, E, Allen, P G, Huang, P L, Böhm, M, Schoen, F J, Moskowitz, M A, Liao, J K
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - antagonists & inhibitors Actins - physiology Animals Cerebrovascular Circulation - drug effects Cytochalasin D - pharmacology Cytoskeleton - drug effects Cytoskeleton - physiology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Male Mice Mice, Inbred C57BL Neuroprotective Agents - pharmacology Nitric Oxide - physiology Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III rhoA GTP-Binding Protein - physiology RNA, Messenger - analysis Simvastatin - pharmacology
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