The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion

Natural models of heart regeneration in lower vertebrates such as zebrafish are based on invasive surgeries causing mechanical injuries that are limited in size. Here, we created a genetic cell ablation model in zebrafish that facilitates inducible destruction of a high percentage of cardiomyocytes....

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Veröffentlicht in:	Development (Cambridge) 2011-08, Vol.138 (16), p.3421-3430
Hauptverfasser:	Wang, Jinhu, Panáková, Daniela, Kikuchi, Kazu, Holdway, Jennifer E, Gemberling, Matthew, Burris, James S, Singh, Sumeet Pal, Dickson, Amy L, Lin, Yi-Fan, Sabeh, M Khaled, Werdich, Andreas A, Yelon, Deborah, Macrae, Calum A, Poss, Kenneth D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Death Danio rerio Freshwater Heart - physiology Heart Failure - genetics Heart Failure - pathology Myocytes, Cardiac - cytology Regeneration Zebrafish - genetics Zebrafish - physiology
Online-Zugang:	Volltext
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