Night work and inflammatory markers
Background: Various adverse health effects associated with shift work have been documented in the medical literature. These include increased risk of cardiovascular disorders, cerebrovascular disorders, and mortality. Sleep deprivation has been shown to be associated with an elevation in inflammator...
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| Veröffentlicht in: | Indian journal of occupational and environmental medicine 2011-01, Vol.15 (1), p.38-41 |
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| creator | Khosro, Sadeghniiat Alireza, Safaiyan Omid, Aminian Forough, Sharifi |
| description | Background: Various adverse health effects associated with shift work
have been documented in the medical literature. These include increased
risk of cardiovascular disorders, cerebrovascular disorders, and
mortality. Sleep deprivation has been shown to be associated with an
elevation in inflammatory makers such as interleukin 6 (IL-6), tumor
necrosis factor-alpha (TNF-α), and C-reactive protein (CRP). It is
hypothesized that the increased risk of many disorders associated with
shift work may be due to inflammatory processes resulting from sleep
deprivation. The purpose of this study was to investigate the
relationship between night work and inflammatory markers. Materials and
Methods: Fifty workers were selected according to the specified
inclusion and exclusion criteria and randomly assigned to one of two
groups in a cross over study. The 25 workers in group 1 were scheduled
to work the following consecutive shifts: three day shifts, one day
off, and three night shifts. Group 2 were scheduled to work the
following consecutive shifts: three night shifts, one day off, and
three day shifts. Blood samples were obtained between 7:A.M. and 8:A.M.
after the periods of day work and night work and tested for
inflammatory markers. Statistical Analyses: SPSS 11.5 and S-data were
used to analyze data using the Student′s t-test and paired
t-test. Results: There was a statistically significant increase in
IL-6, CRP, white blood cells, neutrophils, lymphocytes, and platelets
following night work compared with day work. TNF-α was increased
but it was not statistically significant, and also the change in
monocyte counts was not significant. Conclusion: This study
demonstrated an increase in inflammatory markers following night work,
as reported in several pervious studies on sleep deprivation. No
significant changes in monocyte count can be justified by the results
of a study which showed that the elevation in blood levels of
inflammatory markers is due to increase in gene expression, not in
monocyte counts. |
| doi_str_mv | 10.4103/0019-5278.82996 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3143516</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A261917900</galeid><sourcerecordid>A261917900</sourcerecordid><originalsourceid>FETCH-LOGICAL-b5416-3e17292da84ba2dfe889fc8da08fbc620004d3521e0b1474a3c38003d96215ce3</originalsourceid><addsrcrecordid>eNqFkt1rFDEUxYModl199k0WC_o023uTzEzyIpTiFxR90eeQyWR2084kNZlR-t-bcdu1KwuSQCD53cu5J4eQlwhrjsDOAFAWJa3FWlApq0dkgVKKglU1PCYLkDUrKBX8hDxL6QqAlVjJp-SEogBRAizI6Re32Y6rXyFer7RvV853vR4GPYZ4uxp0vLYxPSdPOt0n--LuXJLvH95_u_hUXH79-Pni_LJoSo5VwSzWVNJWC95o2nZWCNkZ0WoQXWMqCgC8ZSVFCw3ymmtmmMiaWllRLI1lS_Ju1_dmagbbGuvHqHt1E10WcquCdurwxbut2oSfiiGfJ8sN3t41iOHHZNOoBpeM7XvtbZiSkohY1VUt_ksKAdlOhmUmX_9DXoUp-uyDErUoGeUcM3S6gza6typ7GLI-M7dU57RCibXMgy5JcYTaWG_zMMHbzuXrA359hM-rtYMzRwvePCjYWt2P2xT6aXTBp0PwbAeaGFKKttubjKDmYKk5WGoOlvoTrFzx6uHf7Pn7JP0V27jQO2_3hIlOq_vLMG9EAMl-A1x31Eg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>878532441</pqid></control><display><type>article</type><title>Night work and inflammatory markers</title><source>Medknow Open Access Medical Journals</source><source>Bioline International</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Khosro, Sadeghniiat ; Alireza, Safaiyan ; Omid, Aminian ; Forough, Sharifi</creator><creatorcontrib>Khosro, Sadeghniiat ; Alireza, Safaiyan ; Omid, Aminian ; Forough, Sharifi</creatorcontrib><description>Background: Various adverse health effects associated with shift work
have been documented in the medical literature. These include increased
risk of cardiovascular disorders, cerebrovascular disorders, and
mortality. Sleep deprivation has been shown to be associated with an
elevation in inflammatory makers such as interleukin 6 (IL-6), tumor
necrosis factor-alpha (TNF-α), and C-reactive protein (CRP). It is
hypothesized that the increased risk of many disorders associated with
shift work may be due to inflammatory processes resulting from sleep
deprivation. The purpose of this study was to investigate the
relationship between night work and inflammatory markers. Materials and
Methods: Fifty workers were selected according to the specified
inclusion and exclusion criteria and randomly assigned to one of two
groups in a cross over study. The 25 workers in group 1 were scheduled
to work the following consecutive shifts: three day shifts, one day
off, and three night shifts. Group 2 were scheduled to work the
following consecutive shifts: three night shifts, one day off, and
three day shifts. Blood samples were obtained between 7:A.M. and 8:A.M.
after the periods of day work and night work and tested for
inflammatory markers. Statistical Analyses: SPSS 11.5 and S-data were
used to analyze data using the Student′s t-test and paired
t-test. Results: There was a statistically significant increase in
IL-6, CRP, white blood cells, neutrophils, lymphocytes, and platelets
following night work compared with day work. TNF-α was increased
but it was not statistically significant, and also the change in
monocyte counts was not significant. Conclusion: This study
demonstrated an increase in inflammatory markers following night work,
as reported in several pervious studies on sleep deprivation. No
significant changes in monocyte count can be justified by the results
of a study which showed that the elevation in blood levels of
inflammatory markers is due to increase in gene expression, not in
monocyte counts.</description><identifier>ISSN: 0973-2284</identifier><identifier>EISSN: 1998-3670</identifier><identifier>DOI: 10.4103/0019-5278.82996</identifier><identifier>PMID: 21808500</identifier><language>eng</language><publisher>India: Medknow Publications</publisher><subject>Bioindicators ; Biological markers ; Blood levels ; Body mass index ; C-reactive protein, IL-6, inflammatory markers, platelet, shift work, tumor necrosis factor-α, white blood cells ; Chronic diseases ; Diabetes ; Gene expression ; Influence ; Lymphocytes ; Mortality ; Night work ; Original ; Physiological aspects ; Proteins ; Regression analysis ; Risk factors ; Shift work ; Sleep deprivation ; Sleep disorders ; tumors ; working conditions</subject><ispartof>Indian journal of occupational and environmental medicine, 2011-01, Vol.15 (1), p.38-41</ispartof><rights>Copyright 2011 Indian Journal of Occupational and Environmental Medicine.</rights><rights>COPYRIGHT 2011 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Jan 2011</rights><rights>Copyright: © Indian Journal of Occupational and Environmental Medicine 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b5416-3e17292da84ba2dfe889fc8da08fbc620004d3521e0b1474a3c38003d96215ce3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143516/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143516/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768,79169</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21808500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khosro, Sadeghniiat</creatorcontrib><creatorcontrib>Alireza, Safaiyan</creatorcontrib><creatorcontrib>Omid, Aminian</creatorcontrib><creatorcontrib>Forough, Sharifi</creatorcontrib><title>Night work and inflammatory markers</title><title>Indian journal of occupational and environmental medicine</title><addtitle>Indian J Occup Environ Med</addtitle><description>Background: Various adverse health effects associated with shift work
have been documented in the medical literature. These include increased
risk of cardiovascular disorders, cerebrovascular disorders, and
mortality. Sleep deprivation has been shown to be associated with an
elevation in inflammatory makers such as interleukin 6 (IL-6), tumor
necrosis factor-alpha (TNF-α), and C-reactive protein (CRP). It is
hypothesized that the increased risk of many disorders associated with
shift work may be due to inflammatory processes resulting from sleep
deprivation. The purpose of this study was to investigate the
relationship between night work and inflammatory markers. Materials and
Methods: Fifty workers were selected according to the specified
inclusion and exclusion criteria and randomly assigned to one of two
groups in a cross over study. The 25 workers in group 1 were scheduled
to work the following consecutive shifts: three day shifts, one day
off, and three night shifts. Group 2 were scheduled to work the
following consecutive shifts: three night shifts, one day off, and
three day shifts. Blood samples were obtained between 7:A.M. and 8:A.M.
after the periods of day work and night work and tested for
inflammatory markers. Statistical Analyses: SPSS 11.5 and S-data were
used to analyze data using the Student′s t-test and paired
t-test. Results: There was a statistically significant increase in
IL-6, CRP, white blood cells, neutrophils, lymphocytes, and platelets
following night work compared with day work. TNF-α was increased
but it was not statistically significant, and also the change in
monocyte counts was not significant. Conclusion: This study
demonstrated an increase in inflammatory markers following night work,
as reported in several pervious studies on sleep deprivation. No
significant changes in monocyte count can be justified by the results
of a study which showed that the elevation in blood levels of
inflammatory markers is due to increase in gene expression, not in
monocyte counts.</description><subject>Bioindicators</subject><subject>Biological markers</subject><subject>Blood levels</subject><subject>Body mass index</subject><subject>C-reactive protein, IL-6, inflammatory markers, platelet, shift work, tumor necrosis factor-α, white blood cells</subject><subject>Chronic diseases</subject><subject>Diabetes</subject><subject>Gene expression</subject><subject>Influence</subject><subject>Lymphocytes</subject><subject>Mortality</subject><subject>Night work</subject><subject>Original</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Shift work</subject><subject>Sleep deprivation</subject><subject>Sleep disorders</subject><subject>tumors</subject><subject>working conditions</subject><issn>0973-2284</issn><issn>1998-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkt1rFDEUxYModl199k0WC_o023uTzEzyIpTiFxR90eeQyWR2084kNZlR-t-bcdu1KwuSQCD53cu5J4eQlwhrjsDOAFAWJa3FWlApq0dkgVKKglU1PCYLkDUrKBX8hDxL6QqAlVjJp-SEogBRAizI6Re32Y6rXyFer7RvV853vR4GPYZ4uxp0vLYxPSdPOt0n--LuXJLvH95_u_hUXH79-Pni_LJoSo5VwSzWVNJWC95o2nZWCNkZ0WoQXWMqCgC8ZSVFCw3ymmtmmMiaWllRLI1lS_Ju1_dmagbbGuvHqHt1E10WcquCdurwxbut2oSfiiGfJ8sN3t41iOHHZNOoBpeM7XvtbZiSkohY1VUt_ksKAdlOhmUmX_9DXoUp-uyDErUoGeUcM3S6gza6typ7GLI-M7dU57RCibXMgy5JcYTaWG_zMMHbzuXrA359hM-rtYMzRwvePCjYWt2P2xT6aXTBp0PwbAeaGFKKttubjKDmYKk5WGoOlvoTrFzx6uHf7Pn7JP0V27jQO2_3hIlOq_vLMG9EAMl-A1x31Eg</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Khosro, Sadeghniiat</creator><creator>Alireza, Safaiyan</creator><creator>Omid, Aminian</creator><creator>Forough, Sharifi</creator><general>Medknow Publications</general><general>Medknow Publications and Media Pvt. 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have been documented in the medical literature. These include increased
risk of cardiovascular disorders, cerebrovascular disorders, and
mortality. Sleep deprivation has been shown to be associated with an
elevation in inflammatory makers such as interleukin 6 (IL-6), tumor
necrosis factor-alpha (TNF-α), and C-reactive protein (CRP). It is
hypothesized that the increased risk of many disorders associated with
shift work may be due to inflammatory processes resulting from sleep
deprivation. The purpose of this study was to investigate the
relationship between night work and inflammatory markers. Materials and
Methods: Fifty workers were selected according to the specified
inclusion and exclusion criteria and randomly assigned to one of two
groups in a cross over study. The 25 workers in group 1 were scheduled
to work the following consecutive shifts: three day shifts, one day
off, and three night shifts. Group 2 were scheduled to work the
following consecutive shifts: three night shifts, one day off, and
three day shifts. Blood samples were obtained between 7:A.M. and 8:A.M.
after the periods of day work and night work and tested for
inflammatory markers. Statistical Analyses: SPSS 11.5 and S-data were
used to analyze data using the Student′s t-test and paired
t-test. Results: There was a statistically significant increase in
IL-6, CRP, white blood cells, neutrophils, lymphocytes, and platelets
following night work compared with day work. TNF-α was increased
but it was not statistically significant, and also the change in
monocyte counts was not significant. Conclusion: This study
demonstrated an increase in inflammatory markers following night work,
as reported in several pervious studies on sleep deprivation. No
significant changes in monocyte count can be justified by the results
of a study which showed that the elevation in blood levels of
inflammatory markers is due to increase in gene expression, not in
monocyte counts.</abstract><cop>India</cop><pub>Medknow Publications</pub><pmid>21808500</pmid><doi>10.4103/0019-5278.82996</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0973-2284 |
| ispartof | Indian journal of occupational and environmental medicine, 2011-01, Vol.15 (1), p.38-41 |
| issn | 0973-2284 1998-3670 |
| language | eng |
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| source | Medknow Open Access Medical Journals; Bioline International; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Bioindicators Biological markers Blood levels Body mass index C-reactive protein, IL-6, inflammatory markers, platelet, shift work, tumor necrosis factor-α, white blood cells Chronic diseases Diabetes Gene expression Influence Lymphocytes Mortality Night work Original Physiological aspects Proteins Regression analysis Risk factors Shift work Sleep deprivation Sleep disorders tumors working conditions |
| title | Night work and inflammatory markers |
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