Prenatal Perfluorooctanoic Acid Exposure in CD-1 Mice: Low-Dose Developmental Effects and Internal Dosimetry

Perfluorooctanoic acid (PFOA) is an environmental contaminant that causes adverse developmental effects in laboratory animals. To investigate the low-dose effects of PFOA on offspring, timed-pregnant CD-1 mice were gavage dosed with PFOA for all or half of gestation. In the full-gestation study, mic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicological sciences 2011-07, Vol.122 (1), p.134-145
Hauptverfasser:	Macon, Madisa B., Villanueva, LaTonya R., Tatum-Gibbs, Katoria, Zehr, Robert D., Strynar, Mark J., Stanko, Jason P., White, Sally S., Helfant, Laurence, Fenton, Suzanne E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Body Weight - drug effects Caprylates - blood Caprylates - toxicity Dose-Response Relationship, Drug Female Fluorocarbons - blood Fluorocarbons - toxicity Gestational Age Liver - drug effects Male Mammary Glands, Animal - drug effects Mammary Glands, Animal - pathology Maternal Exposure - adverse effects Mice Mice, Inbred Strains No-Observed-Adverse-Effect Level Organ Size - drug effects Pregnancy Prenatal Exposure Delayed Effects - chemically induced Reproductive and Developmental Toxicology Sensitivity and Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!