Antidepressant-Like Activity of 10-Hydroxy-Trans-2-Decenoic Acid, a Unique Unsaturated Fatty Acid of Royal Jelly, in Stress-Inducible Depression-Like Mouse Model
Symptoms of depression and anxiety appeared in mice after they had been subjected to a combination of forced swimming for 15 min followed by being kept in cages that were sequentially subjected to leaning, drenching, and rotation within 1-2 days for a total of 3 weeks. The animals were then evaluate...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2012-01, Vol.2012 (2012), p.1-6 |
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| creator | Furukawa, Shoei Ikeno, Kumiko Soumiya, Hitomi Fukumitsu, Hidefumi Nitta, Yuji Ito, Satoru Nakamura, Tadashi |
| description | Symptoms of depression and anxiety appeared in mice after they had been subjected to a combination of forced swimming for 15 min followed by being kept in cages that were sequentially subjected to leaning, drenching, and rotation within 1-2 days for a total of 3 weeks. The animals were then evaluated by the tail-suspension test, elevated plus-maze test, and open-field test at 1 day after the end of stress exposure. Using these experimental systems, we found that 10-hydroxy-trans-2-decenoic acid (HDEA), an unsaturated fatty acid unique to royal jelly (RJ), protected against the depression and anxiety when intraperitoneally administered once a day for 3 weeks simultaneously with the stress loading. Intraperitoneally administered RJ, a rich source of HDEA, was also protective against the depression, but RJ given by the oral route was less effective. Our present results demonstrate that HDEA and RJ, a natural source of it, were effective in ameliorating the stress-inducible symptoms of depression and anxiety. |
| doi_str_mv | 10.1155/2012/139140 |
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The animals were then evaluated by the tail-suspension test, elevated plus-maze test, and open-field test at 1 day after the end of stress exposure. Using these experimental systems, we found that 10-hydroxy-trans-2-decenoic acid (HDEA), an unsaturated fatty acid unique to royal jelly (RJ), protected against the depression and anxiety when intraperitoneally administered once a day for 3 weeks simultaneously with the stress loading. Intraperitoneally administered RJ, a rich source of HDEA, was also protective against the depression, but RJ given by the oral route was less effective. Our present results demonstrate that HDEA and RJ, a natural source of it, were effective in ameliorating the stress-inducible symptoms of depression and anxiety.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2012/139140</identifier><identifier>PMID: 21799699</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Antidepressants ; Anxiety ; Brain-derived neurotrophic factor ; Cages ; Fatty acids ; Hypotheses ; Laboratory animals ; Mental depression ; Nervous system ; Neurobiology ; Neurogenesis ; Neurosciences ; Open-field behavior ; Psychiatry ; Psychotropic drugs ; Rodents ; Rotation ; Royal jelly ; Signal transduction ; Stress ; Swimming</subject><ispartof>Evidence-based complementary and alternative medicine, 2012-01, Vol.2012 (2012), p.1-6</ispartof><rights>Copyright © 2012 Satoru Ito et al.</rights><rights>Copyright © 2012 Satoru Ito et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2012 Satoru Ito et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-39d238e61423b9e65fb3e3073c8f345a251900ea850e53ecc476f4413cd3acea3</citedby><cites>FETCH-LOGICAL-c532t-39d238e61423b9e65fb3e3073c8f345a251900ea850e53ecc476f4413cd3acea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143448/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143448/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21799699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mischoulon, David</contributor><contributor>David Mischoulon</contributor><creatorcontrib>Furukawa, Shoei</creatorcontrib><creatorcontrib>Ikeno, Kumiko</creatorcontrib><creatorcontrib>Soumiya, Hitomi</creatorcontrib><creatorcontrib>Fukumitsu, Hidefumi</creatorcontrib><creatorcontrib>Nitta, Yuji</creatorcontrib><creatorcontrib>Ito, Satoru</creatorcontrib><creatorcontrib>Nakamura, Tadashi</creatorcontrib><title>Antidepressant-Like Activity of 10-Hydroxy-Trans-2-Decenoic Acid, a Unique Unsaturated Fatty Acid of Royal Jelly, in Stress-Inducible Depression-Like Mouse Model</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Symptoms of depression and anxiety appeared in mice after they had been subjected to a combination of forced swimming for 15 min followed by being kept in cages that were sequentially subjected to leaning, drenching, and rotation within 1-2 days for a total of 3 weeks. 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Our present results demonstrate that HDEA and RJ, a natural source of it, were effective in ameliorating the stress-inducible symptoms of depression and anxiety.</description><subject>Antidepressants</subject><subject>Anxiety</subject><subject>Brain-derived neurotrophic factor</subject><subject>Cages</subject><subject>Fatty acids</subject><subject>Hypotheses</subject><subject>Laboratory animals</subject><subject>Mental depression</subject><subject>Nervous system</subject><subject>Neurobiology</subject><subject>Neurogenesis</subject><subject>Neurosciences</subject><subject>Open-field behavior</subject><subject>Psychiatry</subject><subject>Psychotropic drugs</subject><subject>Rodents</subject><subject>Rotation</subject><subject>Royal jelly</subject><subject>Signal transduction</subject><subject>Stress</subject><subject>Swimming</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUtv1DAUhSMEoqWwYo8isUAqNfUribNBGrX0gQYhQSuxszz2DXXJ2FPbKeTn8E_rKGVUWLHxteTPx-f4FMVLgt8RUlWHFBN6SFhLOH5U7JKGE8SpEI-3--bbTvEsxmuMads0zdNih5Kmbeu23S1-L1yyBjYBYlQuoaX9AeVCJ3tr01j6riQYnY0m-F8jugjKRUTRMWhw3urMWXNQqvLS2ZsB8ogqDUElMOWJSvn-BEwiX_yo-vIj9P14UFpXfk3Te-jcmUHbVQ_l8ezAejc7-OSHOK0G-ufFk071EV7cz73i8uTDxdEZWn4-PT9aLJGuGE2ItYYyATXhlK1aqKtuxYDhhmnRMV4pWpEWY1CiwlAx0Jo3dcc5YdowpUGxveL9rLsZVmswOWIKqpebYNcqjNIrK_8-cfZKfve3khHOOBdZ4M29QPD5O2KSaxt1zqwc5DhSCJwr4jXJ5Ot_yGs_BJfTSYprLHBN2ol6O1M6-BgDdFsvBMupeTk1L-fmM_3qof0t-6fqDOzPwJV1Rv20_6cGGYFOPYCpwJiwO8cpwFk</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Furukawa, Shoei</creator><creator>Ikeno, Kumiko</creator><creator>Soumiya, Hitomi</creator><creator>Fukumitsu, Hidefumi</creator><creator>Nitta, Yuji</creator><creator>Ito, Satoru</creator><creator>Nakamura, Tadashi</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Antidepressant-Like Activity of 10-Hydroxy-Trans-2-Decenoic Acid, a Unique Unsaturated Fatty Acid of Royal Jelly, in Stress-Inducible Depression-Like Mouse Model</title><author>Furukawa, Shoei ; Ikeno, Kumiko ; Soumiya, Hitomi ; Fukumitsu, Hidefumi ; Nitta, Yuji ; Ito, Satoru ; Nakamura, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-39d238e61423b9e65fb3e3073c8f345a251900ea850e53ecc476f4413cd3acea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antidepressants</topic><topic>Anxiety</topic><topic>Brain-derived neurotrophic factor</topic><topic>Cages</topic><topic>Fatty acids</topic><topic>Hypotheses</topic><topic>Laboratory animals</topic><topic>Mental depression</topic><topic>Nervous system</topic><topic>Neurobiology</topic><topic>Neurogenesis</topic><topic>Neurosciences</topic><topic>Open-field behavior</topic><topic>Psychiatry</topic><topic>Psychotropic drugs</topic><topic>Rodents</topic><topic>Rotation</topic><topic>Royal jelly</topic><topic>Signal transduction</topic><topic>Stress</topic><topic>Swimming</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furukawa, Shoei</creatorcontrib><creatorcontrib>Ikeno, Kumiko</creatorcontrib><creatorcontrib>Soumiya, Hitomi</creatorcontrib><creatorcontrib>Fukumitsu, Hidefumi</creatorcontrib><creatorcontrib>Nitta, Yuji</creatorcontrib><creatorcontrib>Ito, Satoru</creatorcontrib><creatorcontrib>Nakamura, Tadashi</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Antidepressants Anxiety Brain-derived neurotrophic factor Cages Fatty acids Hypotheses Laboratory animals Mental depression Nervous system Neurobiology Neurogenesis Neurosciences Open-field behavior Psychiatry Psychotropic drugs Rodents Rotation Royal jelly Signal transduction Stress Swimming |
| title | Antidepressant-Like Activity of 10-Hydroxy-Trans-2-Decenoic Acid, a Unique Unsaturated Fatty Acid of Royal Jelly, in Stress-Inducible Depression-Like Mouse Model |
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