Paranodal permeability in "myelin mutants"

Fluorescent dextran tracers of varying sizes have been used to assess paranodal permeability in myelinated sciatic nerve fibers from control and three “myelin mutant” mice, Caspr‐null, cst‐null, and shaking. We demonstrate that in all of these the paranode is permeable to small tracers (3 kDa and 10...

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Veröffentlicht in:	Glia 2011-10, Vol.59 (10), p.1447-1457
Hauptverfasser:	Shroff, Seema, Mierzwa, Amanda, Scherer, Steven S., Peles, Elior, Arevalo, Juan C., Chao, Moses V., Rosenbluth, Jack
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals axoglial junction Cell Adhesion Molecules, Neuronal - genetics Cystatins - genetics demyelination demyelination multiple sclerosis Dextran Dextrans - metabolism dysmyelination Fibers Fluorescent indicators Mice Mice, Inbred C57BL Mice, Neurologic Mutants - genetics Microscopy, Electron, Transmission - methods Molecular Weight multiple sclerosis Myelin Myelin Sheath - genetics nerve conduction velocity Nerve Fibers, Myelinated - metabolism Nerve Fibers, Myelinated - ultrastructure neuropathy paraneoplastic syndromes Permeability Ranvier's Nodes - metabolism Ranvier's Nodes - ultrastructure Sciatic nerve Sciatic Nerve - cytology Sciatic Nerve - metabolism Sciatic Nerve - ultrastructure Tracers
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