Molecular Basis of a Million-Fold Affinity Maturation Process in a Protein–Protein Interaction

Protein engineering is becoming increasingly important for pharmaceutical applications where controlling the specificity and affinity of engineered proteins is required to create targeted protein therapeutics. Affinity increases of several thousand-fold are now routine for a variety of protein engin...

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Veröffentlicht in:	Journal of molecular biology 2011-08, Vol.411 (2), p.321-328
Hauptverfasser:	Bonsor, Daniel A., Postel, Sandra, Pierce, Brian G., Wang, Ningyan, Zhu, Penny, Buonpane, Rebecca A., Weng, Zhiping, Kranz, David M., Sundberg, Eric J.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AFFINITY Bacterial Proteins Bacterial Proteins - chemistry Bacterial Proteins - metabolism BASIC BIOLOGICAL SCIENCES BIOLOGY chemistry computational biology CRYSTALLOGRAPHY Crystallography, X-Ray DRUGS metabolism Models, Molecular MUTAGENESIS Mutant Proteins Mutant Proteins - chemistry Mutant Proteins - metabolism Protein Binding PROTEIN ENGINEERING Protein Interaction Mapping Protein Structure, Quaternary protein-protein interactions PROTEINS Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - metabolism SPECIFICITY therapeutics X-ray crystallography X-ray diffraction yeast display YEASTS
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