Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia

Summary Severe congenital neutropenia (SCN) is a heterogeneous bone marrow failure syndrome predisposing to myelodysplastic syndrome and acute myeloid leukaemia (MDS/AML). We studied 82 North American and Australian SCN patients enrolled in the Severe Chronic Neutropenia International Registry who w...

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Veröffentlicht in:	British journal of haematology 2008-01, Vol.140 (2), p.210-213
Hauptverfasser:	Rosenberg, Philip S., Alter, Blanche P., Link, Daniel C., Stein, Steven, Rodger, Elin, Bolyard, Audrey A., Aprikyan, Andrew A., Bonilla, Mary A., Dror, Yigal, Kannourakis, George, Newburger, Peter E., Boxer, Laurence A., Dale, David C.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myeloid leukaemia Australia - epidemiology Biological and medical sciences Chronic Disease Disease Progression Dose-Response Relationship, Drug Epidemiologic Methods Genetic Predisposition to Disease Granulocyte Colony-Stimulating Factor - therapeutic use granulocyte colony‐stimulating factor Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - epidemiology Leukemia, Myeloid, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Elastase - genetics Medical sciences Mutation myelodysplastic syndromes Myelodysplastic Syndromes - epidemiology Myelodysplastic Syndromes - genetics Neutropenia - congenital Neutropenia - drug therapy Neutropenia - epidemiology Neutropenia - genetics neutrophil elastase ELA2 Precancerous Conditions - congenital Precancerous Conditions - drug therapy Precancerous Conditions - epidemiology Precancerous Conditions - genetics severe congenital neutropenia United States - epidemiology
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