Blood Sugar Lowering Effect of Coccinia grandis (L.) J. Voigt : Path for a New Drug for Diabetes Mellitus
Background. Role of herbs in the management and control of diabetes has emerged fast over the years. We assessed the efficacy of Coccinia grandis (locally known as Ken, Kovakka) leaves as a hypoglycemic agent. Methods. Double-blind phase I clinical trial was conducted at the general hospital and a p...
Gespeichert in:
| Veröffentlicht in: | Experimental diabetes research 2011-01, Vol.2011 (2011), p.1-4 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4 |
|---|---|
| container_issue | 2011 |
| container_start_page | 1 |
| container_title | Experimental diabetes research |
| container_volume | 2011 |
| creator | Munasinghe, M. A. A. K. Abeysena, C. Yaddehige, I. S. Vidanapathirana, T. Piyumal, K. P. B. |
| description | Background. Role of herbs in the management and control of diabetes has emerged fast over the years. We assessed the efficacy of Coccinia grandis (locally known as Ken, Kovakka) leaves as a hypoglycemic agent. Methods. Double-blind phase I clinical trial was conducted at the general hospital and a private hospital in Matara in August 2009. All the participants were given a common meal for dinner, and they maintained a 10-hour fasting period. Sixty-one healthy volunteers were given a meal containing 20 g of leaves of Coccinia grandis which was mixed with a measured amount of scraped coconut and table salt for breakfast, and other 61 were given the placebo meal which also contained scraped coconut and salt. Glucose tolerance test was performed blindly for the two groups. Mixed factorial design analysis of variance and student's t-test were applied. Results. Overall blood sugar levels of the experimental group were also significantly lower than those of the control group (F(1,117) 5.56, P |
| doi_str_mv | 10.1155/2011/978762 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3142553</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>883307152</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-532e6b11203a4381ea2d046f2454963c99cfe6a6394bd6d5983bc23ff2a70db23</originalsourceid><addsrcrecordid>eNqFkUmP1DAQhS0EYoaBE2eQb2zqHq-JwwEJeoZNzSKxXK2KU057lI4HO6HFvydNZlpw4lRVqk-vXukRcp-zJedanwrG-WlVmrIQN8gxL0y50JLJm9e94OqI3Mn5gjFVaG1ukyPBjRBKyGMSXnUxNvTL2EKi67jDFPqWnnuPbqDR01V0LvQBaJugb0Kmj9fLJ_T9kn6PoR3oc_oZhg31MVGgH3FHz9LY_hnPAtQ4YKYfsOvCMOa75JaHLuO9q3pCvr0-_7p6u1h_evNu9XK9cIqxYbIusKg5F0yCkoYjiGby7YXSqiqkqyrnsYBCVqpuikZXRtZOSO8FlKyphTwhL2bdy7HeYuOwHxJ09jKFLaRfNkKw_276sLFt_GklV0JrOQk8uhJI8ceIebDbkN30BfQYx2yNkZKVXO9PPZtJl2LOCf3hCmd2n43dZ2PnbCb64d_GDux1GBPwdAY2oW9gF_6j9mCGcULQwwHWXDLD5W9dvJ5F</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>883307152</pqid></control><display><type>article</type><title>Blood Sugar Lowering Effect of Coccinia grandis (L.) J. Voigt : Path for a New Drug for Diabetes Mellitus</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Munasinghe, M. A. A. K. ; Abeysena, C. ; Yaddehige, I. S. ; Vidanapathirana, T. ; Piyumal, K. P. B.</creator><contributor>Raz, I.</contributor><creatorcontrib>Munasinghe, M. A. A. K. ; Abeysena, C. ; Yaddehige, I. S. ; Vidanapathirana, T. ; Piyumal, K. P. B. ; Raz, I.</creatorcontrib><description>Background. Role of herbs in the management and control of diabetes has emerged fast over the years. We assessed the efficacy of Coccinia grandis (locally known as Ken, Kovakka) leaves as a hypoglycemic agent. Methods. Double-blind phase I clinical trial was conducted at the general hospital and a private hospital in Matara in August 2009. All the participants were given a common meal for dinner, and they maintained a 10-hour fasting period. Sixty-one healthy volunteers were given a meal containing 20 g of leaves of Coccinia grandis which was mixed with a measured amount of scraped coconut and table salt for breakfast, and other 61 were given the placebo meal which also contained scraped coconut and salt. Glucose tolerance test was performed blindly for the two groups. Mixed factorial design analysis of variance and student's t-test were applied. Results. Overall blood sugar levels of the experimental group were also significantly lower than those of the control group (F(1,117) 5.56, P<0.05). Increase in the blood sugar levels from fasting to one hour (F(1,117) 6.77, P<0.05) and two hours (F(1,117) 5.28, P<0.05) postprandially was statistically significant for participants who were in the control group than those of in the experimental group. The mean difference of postprandial blood sugar levels (mg/dL) after one hour (20.2, 95% confidence interval, 4.81 to 35.5) and two hours (11.46, 95% confidence interval; 1.03 to 21.9) was statistically significant between the two groups. Conclusions. Coccinia grandis has a blood sugar lowering effect. However further studies are needed to validate our findings.</description><identifier>ISSN: 1687-5214</identifier><identifier>EISSN: 1687-5303</identifier><identifier>DOI: 10.1155/2011/978762</identifier><identifier>PMID: 21822423</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adult ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Cucurbitaceae ; Double-Blind Method ; Fasting - blood ; Female ; Glucose Tolerance Test ; Humans ; Hypoglycemic Agents - administration & dosage ; Male ; Plant Leaves ; Plant Preparations - administration & dosage ; Postprandial Period ; Sri Lanka ; Time Factors ; Young Adult</subject><ispartof>Experimental diabetes research, 2011-01, Vol.2011 (2011), p.1-4</ispartof><rights>Copyright © 2011 M. A. A. K. Munasinghe et al.</rights><rights>Copyright © 2011 M. A. A. K. Munasinghe et al. 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-532e6b11203a4381ea2d046f2454963c99cfe6a6394bd6d5983bc23ff2a70db23</citedby><cites>FETCH-LOGICAL-c400t-532e6b11203a4381ea2d046f2454963c99cfe6a6394bd6d5983bc23ff2a70db23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142553/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142553/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21822423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Raz, I.</contributor><creatorcontrib>Munasinghe, M. A. A. K.</creatorcontrib><creatorcontrib>Abeysena, C.</creatorcontrib><creatorcontrib>Yaddehige, I. S.</creatorcontrib><creatorcontrib>Vidanapathirana, T.</creatorcontrib><creatorcontrib>Piyumal, K. P. B.</creatorcontrib><title>Blood Sugar Lowering Effect of Coccinia grandis (L.) J. Voigt : Path for a New Drug for Diabetes Mellitus</title><title>Experimental diabetes research</title><addtitle>Exp Diabetes Res</addtitle><description>Background. Role of herbs in the management and control of diabetes has emerged fast over the years. We assessed the efficacy of Coccinia grandis (locally known as Ken, Kovakka) leaves as a hypoglycemic agent. Methods. Double-blind phase I clinical trial was conducted at the general hospital and a private hospital in Matara in August 2009. All the participants were given a common meal for dinner, and they maintained a 10-hour fasting period. Sixty-one healthy volunteers were given a meal containing 20 g of leaves of Coccinia grandis which was mixed with a measured amount of scraped coconut and table salt for breakfast, and other 61 were given the placebo meal which also contained scraped coconut and salt. Glucose tolerance test was performed blindly for the two groups. Mixed factorial design analysis of variance and student's t-test were applied. Results. Overall blood sugar levels of the experimental group were also significantly lower than those of the control group (F(1,117) 5.56, P<0.05). Increase in the blood sugar levels from fasting to one hour (F(1,117) 6.77, P<0.05) and two hours (F(1,117) 5.28, P<0.05) postprandially was statistically significant for participants who were in the control group than those of in the experimental group. The mean difference of postprandial blood sugar levels (mg/dL) after one hour (20.2, 95% confidence interval, 4.81 to 35.5) and two hours (11.46, 95% confidence interval; 1.03 to 21.9) was statistically significant between the two groups. Conclusions. Coccinia grandis has a blood sugar lowering effect. However further studies are needed to validate our findings.</description><subject>Adult</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Cucurbitaceae</subject><subject>Double-Blind Method</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Male</subject><subject>Plant Leaves</subject><subject>Plant Preparations - administration & dosage</subject><subject>Postprandial Period</subject><subject>Sri Lanka</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>1687-5214</issn><issn>1687-5303</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkUmP1DAQhS0EYoaBE2eQb2zqHq-JwwEJeoZNzSKxXK2KU057lI4HO6HFvydNZlpw4lRVqk-vXukRcp-zJedanwrG-WlVmrIQN8gxL0y50JLJm9e94OqI3Mn5gjFVaG1ukyPBjRBKyGMSXnUxNvTL2EKi67jDFPqWnnuPbqDR01V0LvQBaJugb0Kmj9fLJ_T9kn6PoR3oc_oZhg31MVGgH3FHz9LY_hnPAtQ4YKYfsOvCMOa75JaHLuO9q3pCvr0-_7p6u1h_evNu9XK9cIqxYbIusKg5F0yCkoYjiGby7YXSqiqkqyrnsYBCVqpuikZXRtZOSO8FlKyphTwhL2bdy7HeYuOwHxJ09jKFLaRfNkKw_276sLFt_GklV0JrOQk8uhJI8ceIebDbkN30BfQYx2yNkZKVXO9PPZtJl2LOCf3hCmd2n43dZ2PnbCb64d_GDux1GBPwdAY2oW9gF_6j9mCGcULQwwHWXDLD5W9dvJ5F</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Munasinghe, M. A. A. K.</creator><creator>Abeysena, C.</creator><creator>Yaddehige, I. S.</creator><creator>Vidanapathirana, T.</creator><creator>Piyumal, K. P. B.</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Blood Sugar Lowering Effect of Coccinia grandis (L.) J. Voigt : Path for a New Drug for Diabetes Mellitus</title><author>Munasinghe, M. A. A. K. ; Abeysena, C. ; Yaddehige, I. S. ; Vidanapathirana, T. ; Piyumal, K. P. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-532e6b11203a4381ea2d046f2454963c99cfe6a6394bd6d5983bc23ff2a70db23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Cucurbitaceae</topic><topic>Double-Blind Method</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Male</topic><topic>Plant Leaves</topic><topic>Plant Preparations - administration & dosage</topic><topic>Postprandial Period</topic><topic>Sri Lanka</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Munasinghe, M. A. A. K.</creatorcontrib><creatorcontrib>Abeysena, C.</creatorcontrib><creatorcontrib>Yaddehige, I. S.</creatorcontrib><creatorcontrib>Vidanapathirana, T.</creatorcontrib><creatorcontrib>Piyumal, K. P. B.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental diabetes research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Munasinghe, M. A. A. K.</au><au>Abeysena, C.</au><au>Yaddehige, I. S.</au><au>Vidanapathirana, T.</au><au>Piyumal, K. P. B.</au><au>Raz, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood Sugar Lowering Effect of Coccinia grandis (L.) J. Voigt : Path for a New Drug for Diabetes Mellitus</atitle><jtitle>Experimental diabetes research</jtitle><addtitle>Exp Diabetes Res</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>4</epage><pages>1-4</pages><issn>1687-5214</issn><eissn>1687-5303</eissn><abstract>Background. Role of herbs in the management and control of diabetes has emerged fast over the years. We assessed the efficacy of Coccinia grandis (locally known as Ken, Kovakka) leaves as a hypoglycemic agent. Methods. Double-blind phase I clinical trial was conducted at the general hospital and a private hospital in Matara in August 2009. All the participants were given a common meal for dinner, and they maintained a 10-hour fasting period. Sixty-one healthy volunteers were given a meal containing 20 g of leaves of Coccinia grandis which was mixed with a measured amount of scraped coconut and table salt for breakfast, and other 61 were given the placebo meal which also contained scraped coconut and salt. Glucose tolerance test was performed blindly for the two groups. Mixed factorial design analysis of variance and student's t-test were applied. Results. Overall blood sugar levels of the experimental group were also significantly lower than those of the control group (F(1,117) 5.56, P<0.05). Increase in the blood sugar levels from fasting to one hour (F(1,117) 6.77, P<0.05) and two hours (F(1,117) 5.28, P<0.05) postprandially was statistically significant for participants who were in the control group than those of in the experimental group. The mean difference of postprandial blood sugar levels (mg/dL) after one hour (20.2, 95% confidence interval, 4.81 to 35.5) and two hours (11.46, 95% confidence interval; 1.03 to 21.9) was statistically significant between the two groups. Conclusions. Coccinia grandis has a blood sugar lowering effect. However further studies are needed to validate our findings.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>21822423</pmid><doi>10.1155/2011/978762</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1687-5214 |
| ispartof | Experimental diabetes research, 2011-01, Vol.2011 (2011), p.1-4 |
| issn | 1687-5214 1687-5303 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3142553 |
| source | MEDLINE; PubMed Central Open Access; PubMed Central |
| subjects | Adult Blood Glucose - drug effects Blood Glucose - metabolism Cucurbitaceae Double-Blind Method Fasting - blood Female Glucose Tolerance Test Humans Hypoglycemic Agents - administration & dosage Male Plant Leaves Plant Preparations - administration & dosage Postprandial Period Sri Lanka Time Factors Young Adult |
| title | Blood Sugar Lowering Effect of Coccinia grandis (L.) J. Voigt : Path for a New Drug for Diabetes Mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T08%3A48%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Blood%20Sugar%20Lowering%20Effect%20of%20Coccinia%20grandis%20(L.)%20J.%20Voigt%20:%20Path%20for%20a%20New%20Drug%20for%20Diabetes%20Mellitus&rft.jtitle=Experimental%20diabetes%20research&rft.au=Munasinghe,%20M.%20A.%20A.%20K.&rft.date=2011-01-01&rft.volume=2011&rft.issue=2011&rft.spage=1&rft.epage=4&rft.pages=1-4&rft.issn=1687-5214&rft.eissn=1687-5303&rft_id=info:doi/10.1155/2011/978762&rft_dat=%3Cproquest_pubme%3E883307152%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=883307152&rft_id=info:pmid/21822423&rfr_iscdi=true |