Inhibition of neuronal voltage-gated sodium channels by brilliant blue G

Brilliant blue G (BBG), best known as an antagonist of P2X7 receptors, was found to inhibit voltage-gated sodium currents in N1E-115 neuroblastoma cells. Sodium currents elicited from a holding potential of -60 mV were blocked with an IC(50) of 2 μM. Block was enhanced in a use-dependent manner at h...

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Veröffentlicht in:	Molecular pharmacology 2011-08, Vol.80 (2), p.247-257
Hauptverfasser:	Jo, Sooyeon, Bean, Bruce P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Dose-Response Relationship, Drug Ion Channel Gating - drug effects Ion Channel Gating - physiology Mice Neurons - drug effects Neurons - metabolism Protein Binding - drug effects Protein Binding - physiology Receptors, Purinergic P2X7 - metabolism Rosaniline Dyes - metabolism Rosaniline Dyes - pharmacology Sodium Channel Blockers - metabolism Sodium Channel Blockers - pharmacology Sodium Channels - metabolism
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