midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice

The functions of parathyroid hormone-related protein (PTHrP) on morphogenesis, cell proliferation, apoptosis, and calcium homeostasis have been attributed to its N terminus. Evidence suggests that many of these effects are not mediated by the N terminus but by the midregion, a nuclear localization s...

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Veröffentlicht in:	The FASEB journal 2010-06, Vol.24 (6), p.1947-1957
Hauptverfasser:	Toribio, Ramiro E, Brown, Holly A, Novince, Chad M, Marlow, Brandlyn, Hernon, Krista, Lanigan, Lisa G, Hildreth, Blake E. III, Werbeck, Jillian L, Shu, Sherry T, Lorch, Gwendolen, Carlton, Michelle, Foley, John, Boyaka, Prosper, McCauley, Laurie K, Rosol, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Blotting, Western Bone and Bones - cytology Bone and Bones - pathology Chondrocytes - cytology Chondrocytes - pathology craniofacial Female Flow Cytometry Gene Expression Profiling Gene Knock-In Techniques Genes, Lethal Hematopoiesis Immunoenzyme Techniques lethality Male Mammary Glands, Animal - growth & development Mammary Glands, Animal - pathology Mice Mice, Inbred C57BL Mice, Knockout Nuclear Localization Signals - deficiency osteoblast Osteoblasts - cytology Osteoblasts - pathology parathyroid Parathyroid Hormone-Related Protein - physiology Research Communications Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Survival Rate
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