Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation

The induction of immediate‐early (IE) genes, including proto‐oncogenes c‐ fos and c‐ jun , correlates well with a nucleosomal response, the phosphorylation of histone H3 and HMG‐14 mediated via extracellular signal regulated kinase or p38 MAP kinase cascades. Phosphorylation is targeted to a minute...

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Veröffentlicht in:	The EMBO journal 2000-07, Vol.19 (14), p.3714-3726
Hauptverfasser:	Clayton, Alison L., Rose, Sally, Barratt, Michael J., Mahadevan, Louis C.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylation Acetylation - drug effects Animals Antibodies - immunology c-fos gene c-jun gene Cell Line Electrophoresis, Polyacrylamide Gel Genes, Immediate-Early - genetics Histone Deacetylase Inhibitors histone H3 Histones - chemistry Histones - immunology Histones - metabolism HMG-14 protein Hydroxamic Acids - pharmacology Lysine - analogs & derivatives Lysine - immunology Lysine - metabolism MAP kinase pathways Mice Mice, Inbred C3H Nucleosomes - chemistry Nucleosomes - genetics Nucleosomes - immunology Nucleosomes - metabolism Phosphopeptides - immunology Phosphopeptides - metabolism Phosphorylation Phosphoserine - immunology Precipitin Tests proto-oncogene induction Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-jun - metabolism Transcriptional Activation
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